6-chloro-4-((3-cyano-2-methoxyphenyl)amino)-N-trideuteromethylpyridazine-3-carboxamide

Base Information

• Chemical Name: 6-chloro-4-((3-cyano-2-methoxyphenyl)amino)-N-trideuteromethylpyridazine-3-carboxamide
• CAS No.: 1609394-52-6
• Molecular Formula: C₁₄H₁₂ClN₅O₂
• Molecular Weight: 320.711

Synonyms:6-chloro-4-((3-cyano-2-methoxyphenyl)amino)-N-trideuteromethylpyridazine-3-carboxamide

Chemical Property of 6-chloro-4-((3-cyano-2-methoxyphenyl)amino)-N-trideuteromethylpyridazine-3-carboxamide

Chemical Property:

Purity/Quality:

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Technology Process of 6-chloro-4-((3-cyano-2-methoxyphenyl)amino)-N-trideuteromethylpyridazine-3-carboxamide

There total 1 articles about 6-chloro-4-((3-cyano-2-methoxyphenyl)amino)-N-trideuteromethylpyridazine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitro-6-cyanophenol (28177-79-9) → 6-chloro-4-((3-cyano-2-methoxyphenyl)amino)-N-trideuteromethylpyridazine-3-carboxamide (1609394-52-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 - 25 °C

2: stannous chloride dihydrate / ethyl acetate / 1.5 h / 80 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 - 25 °C

With stannous chloride dihydrate; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

6-chloro-4-((3-cyano-2-methoxyphenyl)amino)-N-trideuteromethylpyridazine-3-carboxamide (1609394-52-6) → (Z)-6-(cyclopropanecarboxamido)-4-((3-(N’-hydroxycarbamimidoyl)-2-methoxyphenyl)amino)-N-trideuteromethylpyridazine-3-carboxamide

Guidance literature:

Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 0.75 h / 130 °C / Inert atmosphere; Sealed tube

2: potassium hydroxide; hydroxylamine hydrochloride / ethanol / 25.5 h / 80 °C / Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydroxylamine hydrochloride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide; In 1,4-dioxane; ethanol;

upstream raw materials:

2-nitro-6-cyanophenol

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