[6-({4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-methoxy-5-methyl-tetrahydro-pyran-2-yl}-triethylsilanyloxy-methyl)-5-methyl-3,4-bis-triethylsilanyloxy-tetrahydro-pyran-2-yl]-methanol

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Chemical Name:[6-({4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-methoxy-5-methyl-tetrahydro-pyran-2-yl}-triethylsilanyloxy-methyl)-5-methyl-3,4-bis-triethylsilanyloxy-tetrahydro-pyran-2-yl]-methanol
CAS No.:329362-76-7
Molecular Formula:C₅₉H₁₁₀O₉Si₅
Molecular Weight:1103.94
Hs Code.:

[6-({4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-6-[4-(<i>tert</i>-butyl-diphenyl-silanyloxy)-butyl]-2-methoxy-5-methyl-tetrahydro-pyran-2-yl}-triethylsilanyloxy-methyl)-5-methyl-3,4-bis-triethylsilanyloxy-tetrahydro-pyran-2-yl]-methanol

Synonyms:[6-({4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-methoxy-5-methyl-tetrahydro-pyran-2-yl}-triethylsilanyloxy-methyl)-5-methyl-3,4-bis-triethylsilanyloxy-tetrahydro-pyran-2-yl]-methanol

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Chemical Property of [6-({4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-methoxy-5-methyl-tetrahydro-pyran-2-yl}-triethylsilanyloxy-methyl)-5-methyl-3,4-bis-triethylsilanyloxy-tetrahydro-pyran-2-yl]-methanol

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Technology Process of [6-({4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-methoxy-5-methyl-tetrahydro-pyran-2-yl}-triethylsilanyloxy-methyl)-5-methyl-3,4-bis-triethylsilanyloxy-tetrahydro-pyran-2-yl]-methanol

There total 8 articles about [6-({4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-methoxy-5-methyl-tetrahydro-pyran-2-yl}-triethylsilanyloxy-methyl)-5-methyl-3,4-bis-triethylsilanyloxy-tetrahydro-pyran-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 329362-62-1
C₆₄H₁₁₈O₁₀Si₅

: 329362-76-7
[6-({4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-methoxy-5-methyl-tetrahydro-pyran-2-yl}-triethylsilanyloxy-methyl)-5-methyl-3,4-bis-triethylsilanyloxy-tetrahydro-pyran-2-yl]-methanol

Guidance literature:: C₆₄H₁₁₈O₁₀Si₅; With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -78 - 0 ℃; for 0.583333h; Inert atmosphere;

With water; sodium hydrogencarbonate; rochelle salt; In tetrahydrofuran; toluene; for 1h;
DOI:10.1016/j.tet.2009.04.001

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 329362-76-7
[6-({4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-methoxy-5-methyl-tetrahydro-pyran-2-yl}-triethylsilanyloxy-methyl)-5-methyl-3,4-bis-triethylsilanyloxy-tetrahydro-pyran-2-yl]-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / 2,6-lutidine / CH₂Cl₂ / -78 °C

2: 91 percent / HCO₂NH₄ / Pd/C / methanol / Heating

3: 82 percent / imidazole / N,N-dimethyl-acetamide

4: 99 percent / 2,6-lutidine / CH₂Cl₂ / -78 °C

5: 81 percent / DIBAL / tetrahydrofuran / -78 - 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; ammonium formate; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1002/1521-3773(20010105)40:1<196::AID-ANIE196>3.0.CO;2-T

Reference yield:

: 200186-26-1
(S)-{2-[(4S,5S,6R)-6-(4-Benzyloxy-butyl)-2,2,5-trimethyl-[1,3]dioxan-4-ylmethyl]-[1,3]dithian-2-yl}-((4aR,6R,7R,8R,8aS)-8-benzyloxy-2,2,7-trimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-methanol

: 329362-76-7
[6-({4-(tert-butyl-dimethyl-silanyloxy)-6-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-2-methoxy-5-methyl-tetrahydro-pyran-2-yl}-triethylsilanyloxy-methyl)-5-methyl-3,4-bis-triethylsilanyloxy-tetrahydro-pyran-2-yl]-methanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 10-camphorsulfonic acid / methanol

1.2: Hg(ClO₄)2; 2,6-lutidine / methanol; tetrahydrofuran

2.1: 76 percent / 4-dimethylaminopyridine / pyridine

3.1: 95 percent / 2,6-lutidine / CH₂Cl₂ / -78 °C

4.1: 91 percent / HCO₂NH₄ / Pd/C / methanol / Heating

5.1: 82 percent / imidazole / N,N-dimethyl-acetamide

6.1: 99 percent / 2,6-lutidine / CH₂Cl₂ / -78 °C

7.1: 81 percent / DIBAL / tetrahydrofuran / -78 - 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; dmap; (1S)-10-camphorsulfonic acid; ammonium formate; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1002/1521-3773(20010105)40:1<196::AID-ANIE196>3.0.CO;2-T