4-(2-(3-chlorophenyl)-6-(thiophen-3-yl)pyridin-4-yl)phenol

Base Information

• Chemical Name: 4-(2-(3-chlorophenyl)-6-(thiophen-3-yl)pyridin-4-yl)phenol
• CAS No.: 1375113-42-0
• Molecular Formula: C₂₁H₁₄ClNOS
• Molecular Weight: 363.867
• Mol file: 1375113-42-0.mol

Synonyms:4-(2-(3-chlorophenyl)-6-(thiophen-3-yl)pyridin-4-yl)phenol

Chemical Property of 4-(2-(3-chlorophenyl)-6-(thiophen-3-yl)pyridin-4-yl)phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(3-chlorophenyl)-6-(thiophen-3-yl)pyridin-4-yl)phenol

There total 3 articles about 4-(2-(3-chlorophenyl)-6-(thiophen-3-yl)pyridin-4-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.9%

1-[2-oxo-2-(thiophen-3-yl)ethyl]pyridinium iodide (1030917-93-1) + 1-(3-chlorophenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (1375113-54-4) → 4-(2-(3-chlorophenyl)-6-(thiophen-3-yl)pyridin-4-yl)phenol (1375113-42-0)

Guidance literature:

With ammonium acetate; acetic acid; at 90 - 110 ℃; for 24h;

DOI:10.1016/j.ejmech.2012.03.010

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(2-(3-chlorophenyl)-6-(thiophen-3-yl)pyridin-4-yl)phenol (1375113-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 20 °C

2: ammonium acetate; acetic acid / 24 h / 90 - 110 °C

With ammonium acetate; acetic acid; sodium hydroxide; In ethanol; water; 1: Claisen Schmidt condensation / 2: Krohnke pyridine synthesis;

DOI:10.1016/j.ejmech.2012.03.010

Reference yield:

1-(thiophen-3-yl)-ethanone (1468-83-3) → 4-(2-(3-chlorophenyl)-6-(thiophen-3-yl)pyridin-4-yl)phenol (1375113-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine / 3 h / 140 °C

2: ammonium acetate; acetic acid / 24 h / 90 - 110 °C

With ammonium acetate; iodine; acetic acid; 2: Krohnke pyridine synthesis;

DOI:10.1016/j.ejmech.2012.03.010

upstream raw materials:

1-(thiophen-3-yl)-ethanone

1-[2-oxo-2-(thiophen-3-yl)ethyl]pyridinium iodide

1-(3-chlorophenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

4-hydroxy-benzaldehyde