Fmoc-Cys(Fnam)-Phe-OMe

Base Information

Chemical Name:Fmoc-Cys(Fnam)-Phe-OMe
CAS No.:233266-64-3
Molecular Formula:C₄₄H₄₄F₄N₄O₇S
Molecular Weight:848.916
Hs Code.:

Synonyms:Fmoc-Cys(Fnam)-Phe-OMe

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Chemical Property of Fmoc-Cys(Fnam)-Phe-OMe

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Technology Process of Fmoc-Cys(Fnam)-Phe-OMe

There total 11 articles about Fmoc-Cys(Fnam)-Phe-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 233266-63-2
N^α-9-fluorenylmethoxycarbonyl-S-[N-[2,3,5,6-tetrafluoro-4-(N'-piperidino)phenyl]-N-(allyloxycarbonyl)aminomethyl]cysteine

: 233266-64-3
Fmoc-Cys(Fnam)-Phe-OMe

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
DOI:10.1016/S0040-4020(99)00323-3

Reference yield:

: 110-89-4
piperidine

: 233266-64-3
Fmoc-Cys(Fnam)-Phe-OMe

Guidance literature:: Multi-step reaction with 6 steps

1.1: 93 percent / dimethylformamide / 72 h / 20 °C

2.1: sodium hydride / dimethylformamide

2.2: 83 percent / dimethylformamide / 2 h / 20 °C

3.1: 71 percent / CH₂Cl₂ / 8 h / 20 °C

4.1: 70 percent / diisopropylethylamine / CH₂Cl₂ / 20 °C

5.1: 77 percent / zinc; acetic acid / 2 h / 20 °C

6.1: 63 percent / BOP; diisopropylethylamine

With sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In dichloromethane; N,N-dimethyl-formamide; 1.1: Substitution / 2.1: Metallation / 2.2: Alkylation / 3.1: Alkylation / 4.1: Condensation / 5.1: Reduction / 6.1: Condensation;
DOI:10.1016/S0040-4020(99)00323-3

Reference yield:

: 771-60-8
2,3,4,5,6-pentafluoroaniline

: 233266-64-3
Fmoc-Cys(Fnam)-Phe-OMe

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethylmagnesium chloride / tetrahydrofuran / 1 h / 20 °C

1.2: 96 percent / tetrahydrofuran / 24 h / 50 °C

2.1: 93 percent / dimethylformamide / 72 h / 20 °C

3.1: sodium hydride / dimethylformamide

3.2: 83 percent / dimethylformamide / 2 h / 20 °C

4.1: 71 percent / CH₂Cl₂ / 8 h / 20 °C

5.1: 70 percent / diisopropylethylamine / CH₂Cl₂ / 20 °C

6.1: 77 percent / zinc; acetic acid / 2 h / 20 °C

7.1: 63 percent / BOP; diisopropylethylamine

With ethylmagnesium chloride; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Acylation / 2.1: Substitution / 3.1: Metallation / 3.2: Alkylation / 4.1: Alkylation / 5.1: Condensation / 6.1: Reduction / 7.1: Condensation;
DOI:10.1016/S0040-4020(99)00323-3