ethyl 4-{(2S)-2-[4-(4-chlorophenoxy)phenoxymethyl]pyrrolidin-1-yl}butyrate

Base Information

Chemical Name:ethyl 4-{(2S)-2-[4-(4-chlorophenoxy)phenoxymethyl]pyrrolidin-1-yl}butyrate
CAS No.:1198149-97-1
Molecular Formula:C₂₃H₂₈ClNO₄
Molecular Weight:417.933
Hs Code.:

Synonyms:ethyl 4-{(2S)-2-[4-(4-chlorophenoxy)phenoxymethyl]pyrrolidin-1-yl}butyrate

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Chemical Property of ethyl 4-{(2S)-2-[4-(4-chlorophenoxy)phenoxymethyl]pyrrolidin-1-yl}butyrate

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Technology Process of ethyl 4-{(2S)-2-[4-(4-chlorophenoxy)phenoxymethyl]pyrrolidin-1-yl}butyrate

There total 8 articles about ethyl 4-{(2S)-2-[4-(4-chlorophenoxy)phenoxymethyl]pyrrolidin-1-yl}butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}pyrrolidine

: 2969-81-5
Ethyl 4-bromobutyrate

: 1198149-97-1
ethyl 4-{(2S)-2-[4-(4-chlorophenoxy)phenoxymethyl]pyrrolidin-1-yl}butyrate

Guidance literature:: With potassium carbonate; In acetonitrile; at 55 ℃; for 68h; Large scale reaction;
DOI:10.1021/op900231j

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 1198149-97-1
ethyl 4-{(2S)-2-[4-(4-chlorophenoxy)phenoxymethyl]pyrrolidin-1-yl}butyrate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / dichloromethane / 0 - 20 °C / Industry scale

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Industry scale

2.2: 18 h / 55 °C / Industry scale

3.1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere; Industry scale

3.2: 3 h / pH 10

4.1: potassium carbonate / acetonitrile / 68 h / 50 - 60 °C / Industry scale; Inert atmosphere

With hydrogenchloride; dmap; potassium tert-butylate; potassium carbonate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 106-39-8
bromochlorobenzene

: 1198149-97-1
ethyl 4-{(2S)-2-[4-(4-chlorophenoxy)phenoxymethyl]pyrrolidin-1-yl}butyrate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate; copper(l) iodide; N,N-dimethylglycine hydrochoride / 1,4-dioxane / 20 - 110 °C / Industry scale; Inert atmosphere

2.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 20 °C / Industry scale; Reflux

2.2: 0.67 h / 23 °C / Industry scale

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Industry scale

3.2: 18 h / 55 °C / Industry scale

4.1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere; Industry scale

4.2: 3 h / pH 10

5.1: potassium carbonate / acetonitrile / 68 h / 50 - 60 °C / Industry scale; Inert atmosphere

With hydrogenchloride; copper(l) iodide; chloro-trimethyl-silane; potassium tert-butylate; N,N-dimethylglycine hydrochoride; potassium carbonate; caesium carbonate; sodium iodide; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;