N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-5-methyl-2-(2-isopropylphenyl)pyrimidin-4-amine trifluoroacetic acid

Base Information

Chemical Name:N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-5-methyl-2-(2-isopropylphenyl)pyrimidin-4-amine trifluoroacetic acid
CAS No.:1616598-33-4
Molecular Formula:C₂HF₃O₂*C₂₃H₂₄N₆
Molecular Weight:498.508
Hs Code.:

Synonyms:N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-5-methyl-2-(2-isopropylphenyl)pyrimidin-4-amine trifluoroacetic acid

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Chemical Property of N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-5-methyl-2-(2-isopropylphenyl)pyrimidin-4-amine trifluoroacetic acid

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Technology Process of N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-5-methyl-2-(2-isopropylphenyl)pyrimidin-4-amine trifluoroacetic acid

There total 8 articles about N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-5-methyl-2-(2-isopropylphenyl)pyrimidin-4-amine trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1616598-41-4
N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-2-chloro-5-methylpyrimidin-4-amine

: 89787-12-2
2-isopropylphenylboronic acid

: 76-05-1
trifluoroacetic acid

: 1616598-33-4
N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-5-methyl-2-(2-isopropylphenyl)pyrimidin-4-amine trifluoroacetic acid

Guidance literature:: N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-2-chloro-5-methylpyrimidin-4-amine; 2-isopropylphenylboronic acid; With sodium carbonate; In water; N,N-dimethyl-formamide; at 150 ℃; for 0.5h; Microwave irradiation;

trifluoroacetic acid; In water; acetonitrile; Reagent/catalyst; Concentration; Time;

Reference yield: 30.0%

: N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-2-chloro-5-methylpyrimidin-4-amine trifluoroacetic acid

: 89787-12-2
2-isopropylphenylboronic acid

: 1616598-33-4
N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-5-methyl-2-(2-isopropylphenyl)pyrimidin-4-amine trifluoroacetic acid

Guidance literature:: With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 150 ℃; for 0.5h; Microwave irradiation;
DOI:10.1021/jm5010495

Reference yield:

: 1780-31-0
2,6-dichloro-5-methylpyrimidine

: 1616598-33-4
N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-5-methyl-2-(2-isopropylphenyl)pyrimidin-4-amine trifluoroacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / chloroform / 60 °C / Sealed tube

2: sodium azide; L-proline; potassium carbonate; sodium L-ascorbate; copper(II) sulfate / dimethyl sulfoxide; water / 65 °C

3: sodium carbonate / water; N,N-dimethyl-formamide / 0.5 h / 150 °C / Microwave irradiation

With sodium azide; sodium carbonate; potassium carbonate; copper(II) sulfate; sodium L-ascorbate; triethylamine; L-proline; In chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;