(R)-2-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(1-(4-fluorophenyl)ethyl)ethanamine

Base Information

Chemical Name:(R)-2-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(1-(4-fluorophenyl)ethyl)ethanamine
CAS No.:1569819-65-3
Molecular Formula:C₂₅H₂₄FN
Molecular Weight:357.471
Hs Code.:

Synonyms:(R)-2-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(1-(4-fluorophenyl)ethyl)ethanamine

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Chemical Property of (R)-2-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(1-(4-fluorophenyl)ethyl)ethanamine

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Technology Process of (R)-2-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(1-(4-fluorophenyl)ethyl)ethanamine

There total 4 articles about (R)-2-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(1-(4-fluorophenyl)ethyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1217-39-6
2-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)acetaldehyde

: 374898-01-8
(R)-1-(4-fluorophenyl)ethylamine

: 1569819-65-3
(R)-2-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(1-(4-fluorophenyl)ethyl)ethanamine

Guidance literature:: 2-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)acetaldehyde; (R)-1-(4-fluorophenyl)ethylamine; With phosphotungstic acid hydrate; In 1,2-dichloro-ethane; at 20 ℃; for 0.666667h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

: 2222-33-5
dibenzosuberenon

: 1569819-65-3
(R)-2-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(1-(4-fluorophenyl)ethyl)ethanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / Inert atmosphere

1.2: Reflux

2.1: diisobutylaluminium hydride / hexane / 1 h / Cooling with acetone-dry ice; Inert atmosphere; Sealed tube

3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Sealed tube

4.1: phosphotungstic acid hydrate / 1,2-dichloro-ethane / 0.67 h / 20 °C / Inert atmosphere

4.2: 20 °C

With phosphotungstic acid hydrate; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; mineral oil;

Reference yield:

: 3707-55-9
10,11-Dihydro-5H-dibenzocyclohepten-5-ylidenessigsaeure-ethylester

: 1569819-65-3
(R)-2-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(1-(4-fluorophenyl)ethyl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / hexane / 1 h / Cooling with acetone-dry ice; Inert atmosphere; Sealed tube

2.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Sealed tube

3.1: phosphotungstic acid hydrate / 1,2-dichloro-ethane / 0.67 h / 20 °C / Inert atmosphere

3.2: 20 °C

With phosphotungstic acid hydrate; diisobutylaluminium hydride; Dess-Martin periodane; In hexane; dichloromethane; 1,2-dichloro-ethane;