methyl 2-(((tertbutoxycarbonyl)oxy)(4-fluorophenyl)methyl)acrylate

Base Information

• Chemical Name: methyl 2-(((tertbutoxycarbonyl)oxy)(4-fluorophenyl)methyl)acrylate
• CAS No.: 1132641-31-6
• Molecular Formula: C₁₆H₁₉FO₅
• Molecular Weight: 310.322
• Mol file: 1132641-31-6.mol

Synonyms:methyl 2-(((tertbutoxycarbonyl)oxy)(4-fluorophenyl)methyl)acrylate

Chemical Property of methyl 2-(((tertbutoxycarbonyl)oxy)(4-fluorophenyl)methyl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(((tertbutoxycarbonyl)oxy)(4-fluorophenyl)methyl)acrylate

There total 3 articles about methyl 2-(((tertbutoxycarbonyl)oxy)(4-fluorophenyl)methyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + methyl 3-(4-fluorophenyl)-3-hydroxy-2-methylenepropanoate (353506-65-7) → methyl 2-(((tertbutoxycarbonyl)oxy)(4-fluorophenyl)methyl)acrylate (1132641-31-6)

Guidance literature:

With dmap; In dichloromethane;

DOI:10.1016/j.tet.2013.11.028

Reference yield:

4-fluorobenzaldehyde (459-57-4) → methyl 2-(((tertbutoxycarbonyl)oxy)(4-fluorophenyl)methyl)acrylate (1132641-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / methanol

2: dmap / dichloromethane

With 1,4-diaza-bicyclo[2.2.2]octane; dmap; In methanol; dichloromethane;

DOI:10.1016/j.tet.2013.11.028

Reference yield:

methyl 3-(4-fluorophenyl)-3-hydroxy-2-methylenepropanoate (353506-65-7) → methyl 2-(((tertbutoxycarbonyl)oxy)(4-fluorophenyl)methyl)acrylate (1132641-31-6)

Guidance literature:

With dmap; di-tert-butyl dicarbonate; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1039/c7ob03009f

upstream raw materials:

di-tert-butyl dicarbonate

methyl 3-(4-fluorophenyl)-3-hydroxy-2-methylenepropanoate

4-fluorobenzaldehyde

Downstream raw materials:

C₂₃H₁₇FN₂O₂S

tert-butyl 3-(1-(4-fluorophenyl)-2-(methoxycarbonyl)allyl)-2-oxo-3-phenylindoline-1-carboxylate

methyl (R)-2-{[1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl](4-fluorophenyl)methyl}acrylate

(R)-methyl 2-((diethylphosphoryl)(4-fluorophenyl)methyl)acrylate