4-(5-methyl-2-phenylthiazolo[5,4-d]pyrimidin-7-yl)morpholine

Base Information

• Chemical Name: 4-(5-methyl-2-phenylthiazolo[5,4-d]pyrimidin-7-yl)morpholine
• CAS No.: 1385059-22-2
• Molecular Formula: C₁₆H₁₆N₄OS
• Molecular Weight: 312.395
• Mol file: 1385059-22-2.mol

Synonyms:4-(5-methyl-2-phenylthiazolo[5,4-d]pyrimidin-7-yl)morpholine

Chemical Property of 4-(5-methyl-2-phenylthiazolo[5,4-d]pyrimidin-7-yl)morpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(5-methyl-2-phenylthiazolo[5,4-d]pyrimidin-7-yl)morpholine

There total 3 articles about 4-(5-methyl-2-phenylthiazolo[5,4-d]pyrimidin-7-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

iodobenzene (591-50-4) + 4-(5-methylthiazolo[5,4-d]pyrimidin-7-yl)morpholine (1385059-66-4) → 4-(5-methyl-2-phenylthiazolo[5,4-d]pyrimidin-7-yl)morpholine (1385059-22-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver carbonate; In water; at 60 ℃; for 24h;

DOI:10.1039/c2gc35399g

Reference yield: 80.0%

4-(5-methylthiazolo[5,4-d]pyrimidin-7-yl)morpholine (1385059-66-4) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 4-(5-methyl-2-phenylthiazolo[5,4-d]pyrimidin-7-yl)morpholine (1385059-22-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; tetra-(n-butyl)ammonium iodide; silver carbonate; Trimethylacetic acid; at 120 ℃; for 20h; Reagent/catalyst; Sealed tube;

DOI:10.1016/j.tet.2014.03.103

Reference yield:

7-chloro-2-methylthiazolo[5,4-d]pyrimidine (13316-09-1) → 4-(5-methyl-2-phenylthiazolo[5,4-d]pyrimidin-7-yl)morpholine (1385059-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 12 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver carbonate / water / 24 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver carbonate; In ethanol; water;

DOI:10.1039/c2gc35399g

upstream raw materials:

iodobenzene

4-(5-methylthiazolo[5,4-d]pyrimidin-7-yl)morpholine

7-chloro-2-methylthiazolo[5,4-d]pyrimidine

benzene