Masitinib

Base Information Edit

Chemical Name:Masitinib
CAS No.:790299-79-5
Molecular Formula:C28H30N6OS
Molecular Weight:498.652
Hs Code.:
UNII:M59NC4E26P
DSSTox Substance ID:DTXSID001000207
Nikkaji Number:J2.920.360A
Wikipedia:Masitinib
Wikidata:Q1907109
NCI Thesaurus Code:C79910
Pharos Ligand ID:LRRGQ4BC2VP3
Metabolomics Workbench ID:62788
ChEMBL ID:CHEMBL1908391
Mol file:790299-79-5.mol

Synonyms:4-((4-methylpiperazin-1-yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)-1,3-thiazol-2-yl)amino)phenyl)benzamide;AB 1010;AB-1010;AB1010;Kinavet;kinavet CA-1;masatinib;Masican;masitinib;masitinib mesilate;masitinib mesylate;masitinib methanesulfonate;masivet;Masiviera

Suppliers and Price of Masitinib

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Masitinib
200mg
$ 790.00

TRC
Masitinib
25mg
$ 120.00

DC Chemicals
Masitinib >98%
100 mg
$ 150.00

DC Chemicals
Masitinib >98%
250 mg
$ 300.00

DC Chemicals
Masitinib >98%
1 g
$ 600.00

ChemScene
Masitinib 99.94%
1g
$ 900.00

ChemScene
Masitinib 99.94%
2g
$ 1440.00

ChemScene
Masitinib 99.94%
500mg
$ 540.00

ChemScene
Masitinib 99.94%
50mg
$ 108.00

ChemScene
Masitinib 99.94%
10mg
$ 60.00

Total 142 raw suppliers

Chemical Property of Masitinib Edit

Chemical Property:

Melting Point:90-95oC
Refractive Index:1.682
PKA:13.24±0.70(Predicted)
PSA：101.63000
Density:1.281 g/cm³
LogP:5.27860
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:4.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:498.22018078
Heavy Atom Count:36
Complexity:696

Purity/Quality:

99%MIN ^*data from raw suppliers

Masitinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5
Recent ClinicalTrials:Masitinib in Severe Indolent or Smoldering Systemic Mastocytosis Unresponsive to Optimal Symptomatic Treatment
Recent EU Clinical Trials:A 24-week, multicenter, randomized, double blind, placebo-controlled, dose-range finding phase II study to compare efficacy and safety of oral masitinib to placebo in treatment of patients with severe mast cell activation syndrome (MCAS) with handicap unresponsive to optimal symptomatic treatment
Uses Masitinib is a novel tyrosine kinase inhibitor (TKI) being developed by AB Science to treat symptoms of amyotrophic lateral sclerosis (ALS). Masitinib controlled-release implant for treating solid neoplasm.

Technology Process of Masitinib

There total 9 articles about Masitinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 660837-08-1
N₁-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]-6-methyl-1,3-phenylenediamine

: 314268-40-1
4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester

: 790299-79-5
masitinib

Guidance literature:: N₁-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]-6-methyl-1,3-phenylenediamine; With trimethylaluminum; In hexane; dichloromethane; at 5 - 15 ℃; for 2h;

4-((4-methylpiperazin-1-yl)methyl)-benzoic acid methyl ester; In hexane; dichloromethane; at 20 ℃; for 21.1667h; Heating / reflux;

With sodium hydroxide; water; In hexane; dichloromethane; at 20 ℃; for 3h; Product distribution / selectivity;