(S)-2,3,4,5,6,7-hexahydro-3-phenyl-5-trifluoromethyl-1,4-oxazepine-7-one

Base Information

Chemical Name:(S)-2,3,4,5,6,7-hexahydro-3-phenyl-5-trifluoromethyl-1,4-oxazepine-7-one
CAS No.:1149677-56-4
Molecular Formula:C₁₂H₁₂F₃NO₂
Molecular Weight:259.228
Hs Code.:

Synonyms:(S)-2,3,4,5,6,7-hexahydro-3-phenyl-5-trifluoromethyl-1,4-oxazepine-7-one

Suppliers and Price of (S)-2,3,4,5,6,7-hexahydro-3-phenyl-5-trifluoromethyl-1,4-oxazepine-7-one

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Chemical Property of (S)-2,3,4,5,6,7-hexahydro-3-phenyl-5-trifluoromethyl-1,4-oxazepine-7-one

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Technology Process of (S)-2,3,4,5,6,7-hexahydro-3-phenyl-5-trifluoromethyl-1,4-oxazepine-7-one

There total 4 articles about (S)-2,3,4,5,6,7-hexahydro-3-phenyl-5-trifluoromethyl-1,4-oxazepine-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1149677-53-1
(S)-2,3,4,7-tetrahydro-3-phenyl-5-trifluoromethyl-1,4-oxazepine-7-one

: 1149677-56-4
(S)-2,3,4,5,6,7-hexahydro-3-phenyl-5-trifluoromethyl-1,4-oxazepine-7-one

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In 1,4-dioxane; dichloromethane; at -78 - 20 ℃; for 96h; optical yield given as %de;
DOI:10.1016/j.tetlet.2009.01.159

Reference yield:

: 1149677-53-1
(S)-2,3,4,7-tetrahydro-3-phenyl-5-trifluoromethyl-1,4-oxazepine-7-one

: 1149677-56-4
(S)-2,3,4,5,6,7-hexahydro-3-phenyl-5-trifluoromethyl-1,4-oxazepine-7-one

: C₁₂H₁₂F₃NO₂

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 48h; optical yield given as %de;
DOI:10.1016/j.tetlet.2009.01.159

Reference yield:

: C₁₄H₁₆F₃NO₃

: 1149677-56-4
(S)-2,3,4,5,6,7-hexahydro-3-phenyl-5-trifluoromethyl-1,4-oxazepine-7-one

Guidance literature:: Multi-step reaction with 2 steps

1: stannic bromide / o-xylene / 24 h / Inert atmosphere; Reflux

2: sodium cyanoborohydride; hydrogenchloride / chloroform; dichloromethane; 1,4-dioxane / 48 h / -78 - 20 °C / Inert atmosphere

With hydrogenchloride; stannic bromide; sodium cyanoborohydride; In 1,4-dioxane; dichloromethane; chloroform; o-xylene;
DOI:10.1039/c8nj05668d