(3aS,4S,5S,6R,7R,7aS)-6-(1-ethynyl)-2,2-dimethyl-7-[4-methylphenyl(propioloyl)sulfonamido]-4,5-di(phenylcarbonyloxy)perhydro-1,3-benzodioxole

Base Information

Chemical Name:(3aS,4S,5S,6R,7R,7aS)-6-(1-ethynyl)-2,2-dimethyl-7-[4-methylphenyl(propioloyl)sulfonamido]-4,5-di(phenylcarbonyloxy)perhydro-1,3-benzodioxole
CAS No.:922178-28-7
Molecular Formula:C₃₅H₃₁NO₉S
Molecular Weight:641.698
Hs Code.:

Synonyms:(3aS,4S,5S,6R,7R,7aS)-6-(1-ethynyl)-2,2-dimethyl-7-[4-methylphenyl(propioloyl)sulfonamido]-4,5-di(phenylcarbonyloxy)perhydro-1,3-benzodioxole

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Chemical Property of (3aS,4S,5S,6R,7R,7aS)-6-(1-ethynyl)-2,2-dimethyl-7-[4-methylphenyl(propioloyl)sulfonamido]-4,5-di(phenylcarbonyloxy)perhydro-1,3-benzodioxole

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Technology Process of (3aS,4S,5S,6R,7R,7aS)-6-(1-ethynyl)-2,2-dimethyl-7-[4-methylphenyl(propioloyl)sulfonamido]-4,5-di(phenylcarbonyloxy)perhydro-1,3-benzodioxole

There total 11 articles about (3aS,4S,5S,6R,7R,7aS)-6-(1-ethynyl)-2,2-dimethyl-7-[4-methylphenyl(propioloyl)sulfonamido]-4,5-di(phenylcarbonyloxy)perhydro-1,3-benzodioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 872221-89-1
C₃₂H₃₁NO₈S

: 4672-74-6
propiolic acid anhydride

: 922178-28-7
(3aS,4S,5S,6R,7R,7aS)-6-(1-ethynyl)-2,2-dimethyl-7-[4-methylphenyl(propioloyl)sulfonamido]-4,5-di(phenylcarbonyloxy)perhydro-1,3-benzodioxole

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1139/V06-078

Reference yield:

: 160309-18-2
(1R,4R,5S,6R)-4,5-(isopropylidenedioxy)-7-(4'-methylphenylsulfonyl)-7-azabicyclo<4.1.0>hept-2-ene

: 922178-28-7
(3aS,4S,5S,6R,7R,7aS)-6-(1-ethynyl)-2,2-dimethyl-7-[4-methylphenyl(propioloyl)sulfonamido]-4,5-di(phenylcarbonyloxy)perhydro-1,3-benzodioxole

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / toluene / 0.17 h / 0 °C

1.2: AlCl₃ / toluene / 18 h / 0 - 20 °C

2.1: 46 percent / N-methylmorpholine-N-oxide; OsO₄ / CH₂Cl₂ / 3 h / 20 °C

3.1: 80 percent / pyridine / 1.5 h / 20 °C

4.1: 76 percent / tetrabutylammoinum triphenyldifluorosilicate / acetonitrile / 1.5 h / 20 °C

5.1: 46 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0 - 20 °C

With pyridine; osmium(VIII) oxide; n-butyllithium; sodium hexamethyldisilazane; 4-methylmorpholine N-oxide; tetrabutylammonium triphenyldifluorosilicate; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1139/V06-078

Reference yield:

: N-((1R,2R,5R,6S)-5,6-Dihydroxy-2-trimethylsilanylethynyl-cyclohex-3-enyl)-4-methyl-benzenesulfonamide

: 922178-28-7
(3aS,4S,5S,6R,7R,7aS)-6-(1-ethynyl)-2,2-dimethyl-7-[4-methylphenyl(propioloyl)sulfonamido]-4,5-di(phenylcarbonyloxy)perhydro-1,3-benzodioxole

Guidance literature:: Multi-step reaction with 5 steps

1: 2.14 mmol / p-toluenesulfonic acid / acetone / 0.25 h / 20 °C

2: 46 percent / N-methylmorpholine-N-oxide; OsO₄ / CH₂Cl₂ / 3 h / 20 °C

3: 80 percent / pyridine / 1.5 h / 20 °C

4: 76 percent / tetrabutylammoinum triphenyldifluorosilicate / acetonitrile / 1.5 h / 20 °C

5: 46 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0 - 20 °C

With pyridine; osmium(VIII) oxide; sodium hexamethyldisilazane; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; tetrabutylammonium triphenyldifluorosilicate; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;
DOI:10.1139/V06-078