1-[2-(2-chloro-4-methylphenylsulfanyl)phenyl]piperazine hydrochloride

Base Information

Chemical Name:1-[2-(2-chloro-4-methylphenylsulfanyl)phenyl]piperazine hydrochloride
CAS No.:1293343-10-8
Molecular Formula:C₁₇H₁₉ClN₂S*ClH
Molecular Weight:355.331
Hs Code.:

Synonyms:1-[2-(2-chloro-4-methylphenylsulfanyl)phenyl]piperazine hydrochloride

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Chemical Property of 1-[2-(2-chloro-4-methylphenylsulfanyl)phenyl]piperazine hydrochloride

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Technology Process of 1-[2-(2-chloro-4-methylphenylsulfanyl)phenyl]piperazine hydrochloride

There total 4 articles about 1-[2-(2-chloro-4-methylphenylsulfanyl)phenyl]piperazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1293343-79-9
4-[2-(2-chloro-4-methylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester

: 1293343-10-8
1-[2-(2-chloro-4-methylphenylsulfanyl)phenyl]piperazine hydrochloride

Guidance literature:: With hydrogenchloride; methanol; In diethyl ether; at 20 ℃;
DOI:10.1021/jm101459g

Reference yield:

: 1293343-42-6
1-(2-bromophenylsulfanyl)-2-chloro-4-methylbenzene

: 1293343-10-8
1-[2-(2-chloro-4-methylphenylsulfanyl)phenyl]piperazine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 100 °C

2: hydrogenchloride; methanol / diethyl ether / 20 °C

With hydrogenchloride; methanol; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In diethyl ether; toluene;
DOI:10.1021/jm101459g

Reference yield:

: 6320-02-1
o-bromothiophenol

: 1293343-10-8
1-[2-(2-chloro-4-methylphenylsulfanyl)phenyl]piperazine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; bis[2-(diphenylphosphino)phenyl] ether / toluene / 100 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 100 °C

3: hydrogenchloride; methanol / diethyl ether / 20 °C

With hydrogenchloride; methanol; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate; In diethyl ether; toluene;
DOI:10.1021/jm101459g