(R)-2-(3-(di(isopropyl-d7)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenylisobutyrate

Base Information

Chemical Name:(R)-2-(3-(di(isopropyl-d7)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenylisobutyrate
CAS No.:1126611-88-8
Molecular Formula:C₂₆H₃₇NO₃
Molecular Weight:425.474
Hs Code.:

Synonyms:(R)-2-(3-(di(isopropyl-d7)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenylisobutyrate

Suppliers and Price of (R)-2-(3-(di(isopropyl-d7)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenylisobutyrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (R)-2-(3-(di(isopropyl-d7)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenylisobutyrate

Chemical Property:

Purity/Quality:: >98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (R)-2-(3-(di(isopropyl-d7)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenylisobutyrate

There total 8 articles about (R)-2-(3-(di(isopropyl-d7)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenylisobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1191280-58-6
(R)-2-(3-(di(isopropyl-d7)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenol

: 79-30-1
isobutyryl chloride

: 1126611-88-8
(R)-2-(3-(di(isopropyl-d7)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenylisobutyrate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -30 ℃; for 3h;

Reference yield:

: 459430-90-1
[4-(benzyloxy)-3-bromophenyl]methanol

: 1126611-88-8
(R)-2-(3-(di(isopropyl-d7)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenylisobutyrate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / acetone / 5 h

2.1: iodine; magnesium / tetrahydrofuran / 1 h / 80 °C

2.2: 1 h / -30 °C

2.3: -30 - 20 °C

3.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 4 h / 20 °C

3.2: pH 2

4.1: pyridine; thionyl chloride / toluene / 1 h / Reflux

5.1: triethylamine / diethyl ether / 4 h

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 20 °C

7.1: boron trichloride / dichloromethane / 3 h / -78 °C

7.2: 20 °C / pH 9

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -30 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; dihydrogen peroxide; iodine; boron trichloride; potassium carbonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone; toluene;

Reference yield:

: 628711-07-9
benzyl 4-(benzyloxy)-3-bromobenzoate

: 1126611-88-8
(R)-2-(3-(di(isopropyl-d7)amino)-1-phenylpropyl)-4-(hydroxymethyl)phenylisobutyrate

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 20 °C

2.1: potassium carbonate / acetone / 5 h

3.1: iodine; magnesium / tetrahydrofuran / 1 h / 80 °C

3.2: 1 h / -30 °C

3.3: -30 - 20 °C

4.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 4 h / 20 °C

4.2: pH 2

5.1: pyridine; thionyl chloride / toluene / 1 h / Reflux

6.1: triethylamine / diethyl ether / 4 h

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 20 °C

8.1: boron trichloride / dichloromethane / 3 h / -78 °C

8.2: 20 °C / pH 9

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -30 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; dihydrogen peroxide; iodine; boron trichloride; potassium carbonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone; toluene;