4-Amino-N-(2,6-dimethyl-phenyl)-butyramide

Base Information

Chemical Name:4-Amino-N-(2,6-dimethyl-phenyl)-butyramide
CAS No.:102089-65-6
Molecular Formula:C₁₂H₁₈N₂O
Molecular Weight:206.288
Hs Code.:
ChEMBL ID:CHEMBL167681
DSSTox Substance ID:DTXSID70876936
Nikkaji Number:J1.550.908B
Wikidata:Q82858673

Synonyms:102089-65-6;4-Amino-N-(2,6-dimethyl-phenyl)-butyramide;CHEMBL167681;DTXSID70876936;AKOS002681691;Butanamide, 4-amino-N-(2,6-dimethylphenyl)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Amino-N-(2,6-dimethyl-phenyl)-butyramide

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:206.141913202
Heavy Atom Count:15
Complexity:196

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)C)NC(=O)CCCN

Technology Process of 4-Amino-N-(2,6-dimethyl-phenyl)-butyramide

There total 4 articles about 4-Amino-N-(2,6-dimethyl-phenyl)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 102089-65-6
4-amino-N-(2,6-dimethylphenyl)butanamide

Guidance literature:

Reference yield:

: 77470-77-0
N-(2,6-dimethylphenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanamide

: 1445-69-8
2,3-dihydrophthalazine-1,4-dione

: 102089-65-6
4-amino-N-(2,6-dimethylphenyl)butanamide

Guidance literature:: With hydrogenchloride; hydrazine hydrate; Multistep reaction. Yields of byproduct given; 1.) aq. EtOH, reflux, 75 min, 2.) aq. EtOH, reflux, 1 h;
DOI:10.1021/jm00139a007

Reference yield:

: 77470-78-1
5-chloropentano-2',6'-xylidide

: 102089-65-6
4-amino-N-(2,6-dimethylphenyl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1: NaI / ethanol / 48 h / Heating

2: 73 percent / NaOAc*3H₂O / acetic acid; H₂O / 0.5 h

3: 44 percent / dimethylformamide / 2 h / Heating

4: 1.) N₂H₄*H₂O, 2. conc. HCl / 1.) aq. EtOH, reflux, 75 min, 2.) aq. EtOH, reflux, 1 h

With hydrogenchloride; sodium acetate; hydrazine hydrate; sodium iodide; In ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00139a007