(3S,4S)-4-acetoxy-3-<(1R)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>azetidin-2-one

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Chemical Name:(3S,4S)-4-acetoxy-3-<(1R)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>azetidin-2-one
CAS No.:114316-00-6
Molecular Formula:C₂₁H₃₂N₂O₅Si
Molecular Weight:420.581
Hs Code.:

Synonyms:(3S,4S)-4-acetoxy-3-<(1R)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>azetidin-2-one

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Chemical Property of (3S,4S)-4-acetoxy-3-<(1R)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>azetidin-2-one

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Technology Process of (3S,4S)-4-acetoxy-3-<(1R)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>azetidin-2-one

There total 8 articles about (3S,4S)-4-acetoxy-3-<(1R)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 114376-77-1
(3S,4S)-4-acetoxy-3-<(1R)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>-1-(4-methoxyphenyl)azetidin-2-one

: 114316-00-6
(3S,4S)-4-acetoxy-3-<(1R)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>azetidin-2-one

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetonitrile; at 0 ℃; for 0.5h;
DOI:10.1002/jhet.5570250225

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 114316-00-6
(3S,4S)-4-acetoxy-3-<(1R)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>azetidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 41 percent / dicyclohexylcarbodiimide, 1-hydroxy-1H-benzotriazole / tetrahydrofuran / 1 h / Ambient temperature

2: 38 percent / 1N tetrabutylammonium fluoride, molecular sieves ( 4 Angstroems) / tetrahydrofuran / 1.5 h / 0 °C

3: 94 percent / CF₃COOH / CH₂Cl₂ / 3 h / Ambient temperature

4: 33 percent / CH₃COOH, lead tetraaceate / dimethylformamide / 0.08 h / 60 °C

5: 89 percent / 4-dimethylaminopyridine / dimethylformamide; various solvent(s) / 168 h / Ambient temperature

6: 65 percent / ceric(IV)ammonium nitrate / H₂O; acetonitrile / 0.5 h / 0 °C

With lead(IV) acetate; dmap; ammonium cerium(IV) nitrate; 4 A molecular sieve; tetrabutyl ammonium fluoride; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jhet.5570250225

Reference yield:

: 114315-93-4
(2RS,3SR)-N-(t-butoxycarbonylmethyl)-N-(4-methoxyphenyl)-3-carboxy-2,3-epoxypropionamide

: 114316-00-6
(3S,4S)-4-acetoxy-3-<(1R)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>azetidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 41 percent / dicyclohexylcarbodiimide, 1-hydroxy-1H-benzotriazole / tetrahydrofuran / 1 h / Ambient temperature

2: 38 percent / 1N tetrabutylammonium fluoride, molecular sieves ( 4 Angstroems) / tetrahydrofuran / 1.5 h / 0 °C

3: 94 percent / CF₃COOH / CH₂Cl₂ / 3 h / Ambient temperature

4: 33 percent / CH₃COOH, lead tetraaceate / dimethylformamide / 0.08 h / 60 °C

5: 89 percent / 4-dimethylaminopyridine / dimethylformamide; various solvent(s) / 168 h / Ambient temperature

6: 65 percent / ceric(IV)ammonium nitrate / H₂O; acetonitrile / 0.5 h / 0 °C

With lead(IV) acetate; dmap; ammonium cerium(IV) nitrate; 4 A molecular sieve; tetrabutyl ammonium fluoride; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jhet.5570250225