5-((S)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-4-[((S)-3-benzyloxycarbonylamino-3-methoxycarbonyl-propyl)-hydroxy-phosphinoylmethyl]-5-oxo-pentanoic acid tert-butyl ester

Base Information

Chemical Name:5-((S)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-4-[((S)-3-benzyloxycarbonylamino-3-methoxycarbonyl-propyl)-hydroxy-phosphinoylmethyl]-5-oxo-pentanoic acid tert-butyl ester
CAS No.:1026916-08-4
Molecular Formula:C₃₉H₄₇N₂O₁₁P
Molecular Weight:750.783
Hs Code.:

5-((S)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-4-[((S)-3-benzyloxycarbonylamino-3-methoxycarbonyl-propyl)-hydroxy-phosphinoylmethyl]-5-oxo-pentanoic acid tert-butyl ester

Synonyms:5-((S)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-4-[((S)-3-benzyloxycarbonylamino-3-methoxycarbonyl-propyl)-hydroxy-phosphinoylmethyl]-5-oxo-pentanoic acid tert-butyl ester

Suppliers and Price of 5-((S)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-4-[((S)-3-benzyloxycarbonylamino-3-methoxycarbonyl-propyl)-hydroxy-phosphinoylmethyl]-5-oxo-pentanoic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-((S)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-4-[((S)-3-benzyloxycarbonylamino-3-methoxycarbonyl-propyl)-hydroxy-phosphinoylmethyl]-5-oxo-pentanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-((S)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-4-[((S)-3-benzyloxycarbonylamino-3-methoxycarbonyl-propyl)-hydroxy-phosphinoylmethyl]-5-oxo-pentanoic acid tert-butyl ester

There total 14 articles about 5-((S)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-4-[((S)-3-benzyloxycarbonylamino-3-methoxycarbonyl-propyl)-hydroxy-phosphinoylmethyl]-5-oxo-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1026916-08-4
5-((S)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-4-[((S)-3-benzyloxycarbonylamino-3-methoxycarbonyl-propyl)-hydroxy-phosphinoylmethyl]-5-oxo-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 83 percent / NaH / tetrahydrofuran / 20 °C

2: 100 percent / hydrogen / Pd/C / tetrahydrofuran / 5 h

3: H₂O / 2 h / Heating

4: 65 mg / HCl / ethyl acetate

5: 89 percent / DCC / tetrahydrofuran / 4 h / 20 °C

6: 84 percent / tetrahydrofuran; hexane / -78 - 20 °C

7: CH₂Cl₂ / 15 h / 20 °C

8: TFA / CH₂Cl₂; ethanol / 0.42 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydride; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo0507439

Reference yield:

: C₄₂H₅₅N₂O₁₁PSi

: 1026916-08-4
5-((S)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-4-[((S)-3-benzyloxycarbonylamino-3-methoxycarbonyl-propyl)-hydroxy-phosphinoylmethyl]-5-oxo-pentanoic acid tert-butyl ester

Guidance literature:: With trifluoroacetic acid; In ethanol; dichloromethane; at 20 ℃; for 0.416667h;
DOI:10.1021/jo0507439

Reference yield:

: 864683-12-5
2-benzyloxycarbonyl-pentanedioic acid 1-benzyl ester 5-tert-butyl ester

: 1026916-08-4
5-((S)-4-Benzhydryl-2-oxo-oxazolidin-3-yl)-4-[((S)-3-benzyloxycarbonylamino-3-methoxycarbonyl-propyl)-hydroxy-phosphinoylmethyl]-5-oxo-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / hydrogen / Pd/C / tetrahydrofuran / 5 h

2: H₂O / 2 h / Heating

3: 65 mg / HCl / ethyl acetate

4: 89 percent / DCC / tetrahydrofuran / 4 h / 20 °C

5: 84 percent / tetrahydrofuran; hexane / -78 - 20 °C

6: CH₂Cl₂ / 15 h / 20 °C

7: TFA / CH₂Cl₂; ethanol / 0.42 h / 20 °C

With hydrogenchloride; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo0507439