cis-(S)-4-[4-[4-(3-chlorophenyl)-2-oxo-2-λ5-[1,3,2]dioxaphosphinan-2-yloxymethyl]-2,6-dimethyl-benzyl]-2-isopropylphenol

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Chemical Name:cis-(S)-4-[4-[4-(3-chlorophenyl)-2-oxo-2-λ5-[1,3,2]dioxaphosphinan-2-yloxymethyl]-2,6-dimethyl-benzyl]-2-isopropylphenol
CAS No.:1282618-41-0
Molecular Formula:C₂₈H₃₂ClO₅P
Molecular Weight:514.986
Hs Code.:

Synonyms:cis-(S)-4-[4-[4-(3-chlorophenyl)-2-oxo-2-λ5-[1,3,2]dioxaphosphinan-2-yloxymethyl]-2,6-dimethyl-benzyl]-2-isopropylphenol

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Chemical Property of cis-(S)-4-[4-[4-(3-chlorophenyl)-2-oxo-2-λ5-[1,3,2]dioxaphosphinan-2-yloxymethyl]-2,6-dimethyl-benzyl]-2-isopropylphenol

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Technology Process of cis-(S)-4-[4-[4-(3-chlorophenyl)-2-oxo-2-λ5-[1,3,2]dioxaphosphinan-2-yloxymethyl]-2,6-dimethyl-benzyl]-2-isopropylphenol

There total 3 articles about cis-(S)-4-[4-[4-(3-chlorophenyl)-2-oxo-2-λ5-[1,3,2]dioxaphosphinan-2-yloxymethyl]-2,6-dimethyl-benzyl]-2-isopropylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: trans-4-(3-chlorophenyl)-2-(4-nitrophenoxy)-2-oxido-1,3,2-dioxaphosphorinane

: 3,5-dimethyl-4-(3-isopropyl-4-hydroxybenzyl)benzylphosphate monoammonium salt

: 1282618-41-0
cis-(S)-4-[4-[4-(3-chlorophenyl)-2-oxo-2-λ5-[1,3,2]dioxaphosphinan-2-yloxymethyl]-2,6-dimethyl-benzyl]-2-isopropylphenol

Guidance literature:: 3,5-dimethyl-4-(3-isopropyl-4-hydroxybenzyl)benzylphosphate monoammonium salt; With tert-butylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 0.25h;

trans-4-(3-chlorophenyl)-2-(4-nitrophenoxy)-2-oxido-1,3,2-dioxaphosphorinane; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield:

: 848442-55-7
3,5-dimethyl-4-(3-isopropyl-4-hydroxybenzyl)benzyl alcohol

: 1282618-41-0
cis-(S)-4-[4-[4-(3-chlorophenyl)-2-oxo-2-λ5-[1,3,2]dioxaphosphinan-2-yloxymethyl]-2,6-dimethyl-benzyl]-2-isopropylphenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 5-methylsulfanyl-1H-tetrazole / N,N-dimethyl-formamide / 0.67 h / 20 °C

1.2: 0 - 20 °C

2.1: hydrogenchloride; water / 3 h / 20 °C

3.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.25 h / 0 °C

3.2: 16 h / 0 - 20 °C

With hydrogenchloride; 5-methylsulfanyl-1H-tetrazole; tert-butylmagnesium chloride; water; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 852949-71-4
methyl 3,5-dimethyl-[4-(4'-(methoxymethoxy)-3'-iso-propylbenzyl)]benzoate

: 1282618-41-0
cis-(S)-4-[4-[4-(3-chlorophenyl)-2-oxo-2-λ5-[1,3,2]dioxaphosphinan-2-yloxymethyl]-2,6-dimethyl-benzyl]-2-isopropylphenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol / 0.08 h / 100 °C / Microwave irradiation

1.2: 2 h / 0 °C

1.3: 2 h / 20 °C

2.1: 5-methylsulfanyl-1H-tetrazole / N,N-dimethyl-formamide / 0.67 h / 20 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride; water / 3 h / 20 °C

4.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.25 h / 0 °C

4.2: 16 h / 0 - 20 °C

With hydrogenchloride; 5-methylsulfanyl-1H-tetrazole; tert-butylmagnesium chloride; water; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;