1,4-Dibromo-2,3-difluorobenzene

Base Information

• Chemical Name: 1,4-Dibromo-2,3-difluorobenzene
• CAS No.: 156682-52-9
• Molecular Formula: C6H2Br2F2
• Molecular Weight: 271.887
• Hs Code.: 2903999090
• Mol file: 156682-52-9.mol

Synonyms:1,4-Dibromo-2,3-difluorobenzene;

Chemical Property of 1,4-Dibromo-2,3-difluorobenzene

Chemical Property:

• Vapor Pressure: 0.259mmHg at 25°C
• Refractive Index: 1.552
• Boiling Point: 211.9 °C at 760 mmHg
• Flash Point: 82 °C
• PSA: 0.00000
• Density: 2.087 g/cm³
• LogP: 3.48980
• Storage Temp.: 0-10°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,4-Dibromo-2,3-difluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,4-Dibromo-2,3-difluorobenzene is a halogenated benzene used in the preparation of various biologically active compounds such as non-nucleoside reverse transcriptase inhibitors. 1,4-Dibromo-2,3-diflu orobenzene is also used in the synthesis of conjugated polymers for organic photovoltaics. 1,4-Dibromo-2,3-difluorobenzene is a halogenated benzene used in the preparation of various biologically active compounds such as non-nucleoside reverse transcriptase inhibitors. 1,4-Dibromo-2,3-difluorobenzene is also used in the synthesis of conjugated polymers for organic photovoltaics.

Technology Process of 1,4-Dibromo-2,3-difluorobenzene

There total 4 articles about 1,4-Dibromo-2,3-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2,3-difluoro-1,4-phenylene)bis(trimethylsilane) (867366-94-7) → 1,4-dibromo-2,3-difluoro-benzene (156682-52-9)

Guidance literature:

With bromine; In tetrahydrofuran; at 0 - 60 ℃; for 12h; Solvent;

DOI:10.1016/j.polymer.2016.12.040

Reference yield: 78.5%

(2,3-difluoro-1,4-phenylene)bis(trimethylsilane) (867366-94-7) → 1,4-dibromo-2,3-difluoro-benzene (156682-52-9) + (4-bromo-2,3-difluorophenyl)trimethylsilane (1007571-40-5)

Guidance literature:

With bromine; at 0 - 58 ℃; for 2h;

Reference yield:

dibromodifluoromethane (75-61-6) + 1-bromo-2,3-difluorobenzene (38573-88-5) → 1,4-dibromo-2,3-difluoro-benzene (156682-52-9) + 4-bromo-2,3-difluoro(bromodifluoromethyl)benzene

Guidance literature:

1-bromo-2,3-difluorobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -70 - -65 ℃; for 1h; Inert atmosphere;

dibromodifluoromethane; In tetrahydrofuran; hexane; at -70 - 20 ℃; for 1h; Overall yield = 14.5 g; Inert atmosphere;

upstream raw materials:

(2,3-difluoro-1,4-phenylene)bis(trimethylsilane)

ortho-difluorobenzene

dibromodifluoromethane

1-bromo-2,3-difluorobenzene

Downstream raw materials:

4,4'-(2,3-difluoro-1,4-phenylene)dipyridine

1-(4-bromo-2,3-difluorophenyl)-3-methylbutyl methanesulfonate

1-((3S)-1-(1-(4-bromo-2,3-difluorophenyl)-3-methylbutyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

1-(4-bromo-2,3-difluorophenyl)-3-methylbutan-1-ol

Refernces

• 1、 Jeong, Ina,Chae, Sangmin,Yi, Ahra,Kim, Juae,Chun, Ho Hwan,Cho, Jung Hyeong,Kim, Hyo Jung,Suh, Hongsuk. "Syntheses and photovoltaic properties of 6-(2-thienyl)-4H-thieno[3,2-b]indole based conjugated polymers containing fluorinated benzothiadiazole". . p. 115 - 125. Retrieved 2016/12/30.
• 2、 -. "Compound". Paragraph 0050; 0051. . Retrieved 2018/08/28.