2-(4-dimethylaminophenyl)-3-(isonicotinamido)thiazolidin-4-one-5ylacetyl chloride

Base Information

Chemical Name:2-(4-dimethylaminophenyl)-3-(isonicotinamido)thiazolidin-4-one-5ylacetyl chloride
CAS No.:890848-64-3
Molecular Formula:C₁₉H₁₉ClN₄O₃S
Molecular Weight:418.904
Hs Code.:

Synonyms:2-(4-dimethylaminophenyl)-3-(isonicotinamido)thiazolidin-4-one-5ylacetyl chloride

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Chemical Property of 2-(4-dimethylaminophenyl)-3-(isonicotinamido)thiazolidin-4-one-5ylacetyl chloride

Chemical Property:

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Technology Process of 2-(4-dimethylaminophenyl)-3-(isonicotinamido)thiazolidin-4-one-5ylacetyl chloride

There total 3 articles about 2-(4-dimethylaminophenyl)-3-(isonicotinamido)thiazolidin-4-one-5ylacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 2-(4-dimethylaminophenyl)-3-(isonicotinamido)thiazolidin-4-one-5ylacetic acid

: 890848-64-3
2-(4-dimethylaminophenyl)-3-(isonicotinamido)thiazolidin-4-one-5ylacetyl chloride

Guidance literature:: With thionyl chloride; In benzene; for 4h; Reflux;
DOI:10.1002/ardp.201200126 DOI:10.1002/ardp.201200126

Reference yield:

: 100-10-7
4-dimethylamino-benzaldehyde

: 890848-64-3
2-(4-dimethylaminophenyl)-3-(isonicotinamido)thiazolidin-4-one-5ylacetyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: zinc(II) chloride / ethanol; tetrahydrofuran / 10 h / Reflux

2: thionyl chloride / benzene / 4 h / Reflux

With thionyl chloride; zinc(II) chloride; In tetrahydrofuran; ethanol; benzene;
DOI:10.1002/ardp.201200126 DOI:10.1002/ardp.201200126

Reference yield:

: 54-85-3,7640-37-1
isoniazid

: 890848-64-3
2-(4-dimethylaminophenyl)-3-(isonicotinamido)thiazolidin-4-one-5ylacetyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: zinc(II) chloride / ethanol; tetrahydrofuran / 10 h / Reflux

2: thionyl chloride / benzene / 4 h / Reflux

With thionyl chloride; zinc(II) chloride; In tetrahydrofuran; ethanol; benzene;
DOI:10.1002/ardp.201200126 DOI:10.1002/ardp.201200126