Multi-step reaction with 7 steps
1: dichloromethane / 1 h / Cooling
2: pyridine / 100 °C
3: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 22 h / 100 °C / Inert atmosphere
4: hydrogenchloride / diethyl ether / 20 °C
5: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; tetrahydrofuran / 1.25 h / 70 °C
6: water; lithium hydroxide monohydrate / methanol / 70 °C
7: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; tetrahydrofuran / 64 h / 25 - 70 °C / Inert atmosphere
With
pyridine; hydrogenchloride; lithium hydroxide monohydrate; water; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine;
tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; ethyl acetate;