5-(3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

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Chemical Name:5-(3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one
CAS No.:1620089-47-5
Molecular Formula:C₃₃H₃₃FN₆O₄
Molecular Weight:596.661
Hs Code.:

Synonyms:5-(3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

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Chemical Property of 5-(3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

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Technology Process of 5-(3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

There total 8 articles about 5-(3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.6%

: 1620090-01-8
1-methyl-5-(2-methyl-3-(2-oxoimidazolidin-1-yl)phenyl)-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

: 459-46-1
4-Fluorobenzyl bromide

: 1620089-47-5
5-(3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

Guidance literature:: 1-methyl-5-(2-methyl-3-(2-oxoimidazolidin-1-yl)phenyl)-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

4-Fluorobenzyl bromide; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

Reference yield:

: 1620089-71-5
1-(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)imidazolidin-2-one

: 1620089-47-5
5-(3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / water / 0.08 h / Inert atmosphere; Sealed tube

1.2: 16 h / 120 °C / Inert atmosphere; Sealed tube

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 0.5 h / 0 °C

With sodium hydride; potassium carbonate; In water; N,N-dimethyl-formamide;

Reference yield:

: 1620089-70-4
1-(3-bromo-2-methylphenyl)imidazolidin-2-one

: 1620089-47-5
5-(3-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-2-methylphenyl)-1-methyl-3-((4-(morpholine-4-carbonyl)phenyl)amino)pyrazin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / 1,4-dioxane / 0.17 h / Sealed tube; Inert atmosphere

1.2: 16 h / 110 °C / Sealed tube; Inert atmosphere

2.1: potassium carbonate / water / 0.08 h / Inert atmosphere; Sealed tube

2.2: 16 h / 120 °C / Inert atmosphere; Sealed tube

3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

3.2: 0.5 h / 0 °C

With potassium acetate; sodium hydride; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;