(S)-methyl 2-{(Z)-3-[(Z)-3-(2-{(S)-2-[(S)-2-((tert-butoxy)carbonylamino)propanamido]-3-phenylpropanoyl}hydrazono)isoindolin-1-ylidene]ureido}propanoate

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Chemical Name:(S)-methyl 2-{(Z)-3-[(Z)-3-(2-{(S)-2-[(S)-2-((tert-butoxy)carbonylamino)propanamido]-3-phenylpropanoyl}hydrazono)isoindolin-1-ylidene]ureido}propanoate
CAS No.:1403610-67-2
Molecular Formula:C₃₀H₃₇N₇O₇
Molecular Weight:607.666
Hs Code.:

Synonyms:(S)-methyl 2-{(Z)-3-[(Z)-3-(2-{(S)-2-[(S)-2-((tert-butoxy)carbonylamino)propanamido]-3-phenylpropanoyl}hydrazono)isoindolin-1-ylidene]ureido}propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 2-{(Z)-3-[(Z)-3-(2-{(S)-2-[(S)-2-((tert-butoxy)carbonylamino)propanamido]-3-phenylpropanoyl}hydrazono)isoindolin-1-ylidene]ureido}propanoate

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-methyl 2-{(Z)-3-[(Z)-3-(2-{(S)-2-[(S)-2-((tert-butoxy)carbonylamino)propanamido]-3-phenylpropanoyl}hydrazono)isoindolin-1-ylidene]ureido}propanoate

There total 3 articles about (S)-methyl 2-{(Z)-3-[(Z)-3-(2-{(S)-2-[(S)-2-((tert-butoxy)carbonylamino)propanamido]-3-phenylpropanoyl}hydrazono)isoindolin-1-ylidene]ureido}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1403610-65-0
tert-butyl (S)-1-{(S)-1-[(Z)-2-(3-amino-1H-isoindol-1-ylidene)hydrazinyl]-1-oxo-3-phenylpropan-2-ylamino}-1-oxopropan-2-ylcarbamate

: 2491-20-5
L-alanine methyl ester hydrochloride

: 1403610-67-2
(S)-methyl 2-{(Z)-3-[(Z)-3-(2-{(S)-2-[(S)-2-((tert-butoxy)carbonylamino)propanamido]-3-phenylpropanoyl}hydrazono)isoindolin-1-ylidene]ureido}propanoate

Guidance literature:: bis(trichloromethyl) carbonate; L-alanine methyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.08333h;

tert-butyl (S)-1-{(S)-1-[(Z)-2-(3-amino-1H-isoindol-1-ylidene)hydrazinyl]-1-oxo-3-phenylpropan-2-ylamino}-1-oxopropan-2-ylcarbamate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1002/ejoc.201200238

Reference yield:

: 2481-20-1
N-Boc-L-Alanyl-L-phenylalanin-hydrazid

: 1403610-67-2
(S)-methyl 2-{(Z)-3-[(Z)-3-(2-{(S)-2-[(S)-2-((tert-butoxy)carbonylamino)propanamido]-3-phenylpropanoyl}hydrazono)isoindolin-1-ylidene]ureido}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 4 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.08 h / 20 °C

2.2: 20 °C

With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1002/ejoc.201200238

Reference yield:

: 3468-11-9
1-imino-1H-isoindol-3-amine

: 1403610-67-2
(S)-methyl 2-{(Z)-3-[(Z)-3-(2-{(S)-2-[(S)-2-((tert-butoxy)carbonylamino)propanamido]-3-phenylpropanoyl}hydrazono)isoindolin-1-ylidene]ureido}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 4 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.08 h / 20 °C

2.2: 20 °C

With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1002/ejoc.201200238