6-(3-Benzyloxyamino-propionylamino)-hexanoic acid benzyloxy-[2-(phenylcarbamoylmethyl-carbamoyl)-ethyl]-amide

Base Information

Chemical Name:6-(3-Benzyloxyamino-propionylamino)-hexanoic acid benzyloxy-[2-(phenylcarbamoylmethyl-carbamoyl)-ethyl]-amide
CAS No.:108582-74-7
Molecular Formula:C₃₄H₄₃N₅O₆
Molecular Weight:617.745
Hs Code.:

Synonyms:6-(3-Benzyloxyamino-propionylamino)-hexanoic acid benzyloxy-[2-(phenylcarbamoylmethyl-carbamoyl)-ethyl]-amide

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Chemical Property of 6-(3-Benzyloxyamino-propionylamino)-hexanoic acid benzyloxy-[2-(phenylcarbamoylmethyl-carbamoyl)-ethyl]-amide

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Technology Process of 6-(3-Benzyloxyamino-propionylamino)-hexanoic acid benzyloxy-[2-(phenylcarbamoylmethyl-carbamoyl)-ethyl]-amide

There total 6 articles about 6-(3-Benzyloxyamino-propionylamino)-hexanoic acid benzyloxy-[2-(phenylcarbamoylmethyl-carbamoyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: p-Nitrophenyl 3-(benzyloxyamino)propanoate hydrochloride

: (5-{Benzyloxy-[2-(phenylcarbamoylmethyl-carbamoyl)-ethyl]-carbamoyl}-pentyl)-carbamic acid tert-butyl ester; hydrochloride

: 108582-74-7
6-(3-Benzyloxyamino-propionylamino)-hexanoic acid benzyloxy-[2-(phenylcarbamoylmethyl-carbamoyl)-ethyl]-amide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 30 ℃; for 48h;
DOI:10.1246/bcsj.59.2421

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 108582-74-7
6-(3-Benzyloxyamino-propionylamino)-hexanoic acid benzyloxy-[2-(phenylcarbamoylmethyl-carbamoyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Et₃N, i-BuOCOCl; 2) Et₃N / 1) THF, -15 deg C, 15 min; 2) THF, CHCl₃, 3 h, -15 deg C; 20 h, RT

2: HCl / dioxane

3: 92 percent / Et₃N / dimethylformamide / 48 h / 30 °C

With hydrogenchloride; triethylamine; isobutyl chloroformate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.59.2421

Reference yield:

: 108998-69-2
p-nitrophenyl 3-(benzyloxyamino)propanoate hydrochloride

: 108582-74-7
6-(3-Benzyloxyamino-propionylamino)-hexanoic acid benzyloxy-[2-(phenylcarbamoylmethyl-carbamoyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / Et₃N / CHCl₃ / 48 h / 30 °C

2: HCl / dioxane

3: 1) Et₃N, i-BuOCOCl; 2) Et₃N / 1) THF, -15 deg C, 15 min; 2) THF, CHCl₃, 3 h, -15 deg C; 20 h, RT

4: HCl / dioxane

5: 92 percent / Et₃N / dimethylformamide / 48 h / 30 °C

With hydrogenchloride; triethylamine; isobutyl chloroformate; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.59.2421