ethyl 4-[4-(acetylamino)-3-({[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}amino)phenoxy]butanoate

Base Information

Chemical Name:ethyl 4-[4-(acetylamino)-3-({[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}amino)phenoxy]butanoate
CAS No.:808743-56-8
Molecular Formula:C₂₁H₂₃ClF₃N₃O₄
Molecular Weight:473.88
Hs Code.:

Synonyms:ethyl 4-[4-(acetylamino)-3-({[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}amino)phenoxy]butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 4-[4-(acetylamino)-3-({[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}amino)phenoxy]butanoate

Chemical Property:

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Technology Process of ethyl 4-[4-(acetylamino)-3-({[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}amino)phenoxy]butanoate

There total 5 articles about ethyl 4-[4-(acetylamino)-3-({[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}amino)phenoxy]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 175277-52-8
3-chloro-2-(chloromethyl)-5-(trifluoromethyl)pyridine

: 808743-49-9
ethyl 4-[4-(acetylamino)-3-aminophenoxy]butanoate hydrochloride

: 808743-56-8
ethyl 4-[4-(acetylamino)-3-({[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}amino)phenoxy]butanoate

Guidance literature:: With potassium carbonate; sodium iodide; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 3h;

Reference yield:

: 808744-15-2
ethyl 4-[4-(acetylamino)-3-nitrophenoxy]butanoate

: 808743-56-8
ethyl 4-[4-(acetylamino)-3-({[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}amino)phenoxy]butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 3 h / 20 °C / 760.05 Torr

2: hydrogenchloride / 1,4-dioxane; ethanol / 0.5 h / 20 °C

3: potassium carbonate; sodium iodide / DMF (N,N-dimethyl-formamide) / 3 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; sodium iodide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; DMF (N,N-dimethyl-formamide); ethanol;

Reference yield:

: 2969-81-5
Ethyl 4-bromobutyrate

: 808743-56-8
ethyl 4-[4-(acetylamino)-3-({[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}amino)phenoxy]butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 48 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 3 h / 20 °C / 760.05 Torr

3: hydrogenchloride / 1,4-dioxane; ethanol / 0.5 h / 20 °C

4: potassium carbonate; sodium iodide / DMF (N,N-dimethyl-formamide) / 3 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; sodium iodide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; DMF (N,N-dimethyl-formamide); ethanol;