N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl}-2-methylpropyl-4-phenoxybenzamide

Base Information

Chemical Name:N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl}-2-methylpropyl-4-phenoxybenzamide
CAS No.:1436378-47-0
Molecular Formula:C₂₉H₃₅N₃O₃
Molecular Weight:473.615
Hs Code.:

Synonyms:N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl}-2-methylpropyl-4-phenoxybenzamide

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Chemical Property of N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl}-2-methylpropyl-4-phenoxybenzamide

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Technology Process of N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl}-2-methylpropyl-4-phenoxybenzamide

There total 6 articles about N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl}-2-methylpropyl-4-phenoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 2215-77-2
4-Phenoxybenzoic acid

: 1332870-59-3
3-{(2S)-4-[(2S)-2-amino-3-methylbutyl]-2-methylpiperazin-1-yl}phenol

: 1436378-47-0
N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl}-2-methylpropyl-4-phenoxybenzamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 3h;
DOI:10.1021/jm400275h

Reference yield: 72.0%

: 2215-77-2
4-Phenoxybenzoic acid

: 3-{(2S)-4-[(2S)-2-amino-3-methylbutyl]-2-methylpiperazin-1-yl}phenol

: 1436378-47-0
N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl}-2-methylpropyl-4-phenoxybenzamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 3h;

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 1436378-47-0
N-(1S)-1-{[(3S)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl}-2-methylpropyl-4-phenoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / tetrahydrofuran / 2 h / 0 °C

2: borane-THF / tetrahydrofuran / Reflux

3: hydrogenchloride / water / 1 h

4: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / acetonitrile / 3 h / 20 °C

With hydrogenchloride; borane-THF; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jm400275h