2-Thien-2-ylacetohydrazide

Base Information

• Chemical Name: 2-Thien-2-ylacetohydrazide
• CAS No.: 39978-18-2
• Molecular Formula: C6H8 N2 O S
• Molecular Weight: 156.208
• Hs Code.: 2934999090
• NSC Number: 79155
• DSSTox Substance ID: DTXSID70291923
• Wikidata: Q82030019
• Mol file: 39978-18-2.mol

Synonyms:2-thien-2-ylacetohydrazide;39978-18-2;2-(thiophen-2-yl)acetohydrazide;2-(2-thienyl)acetohydrazide;2-thiophen-2-ylacetohydrazide;Thiophene-2-acetyl hydrazide;NSC79155;thiophen-2-yl-acetic acid hydrazide;Oprea1_492478;SCHEMBL965878;2-thienylacetic acid hydrazide;DTXSID70291923;BBL015543;MFCD00985059;NSC-79155;STK035405;AKOS000200340;MS-9960;SB85961;2-(2-Thienyl)acetohydrazide, AldrichCPR;CS-0308611;FT-0704850;EN300-12575;SR-01000390700;SR-01000390700-1;Z58981810

Chemical Property of 2-Thien-2-ylacetohydrazide

Chemical Property:

• Vapor Pressure: 4.9E-06mmHg at 25°C
• Boiling Point: 381.9°Cat760mmHg
• Flash Point: 184.8°C
• PSA: 83.36000
• Density: 1.287g/cm³
• LogP: 1.37170
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 156.03573406
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

98%min ^*data from raw suppliers

2-Thien-2-ylacetohydrazide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)CC(=O)NN

Technology Process of 2-Thien-2-ylacetohydrazide

There total 8 articles about 2-Thien-2-ylacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 2-thiopheneacetate (19432-68-9) → 2?(thiophen?2?yl)acetohydrazide (39978-18-2)

Guidance literature:

With hydrazine hydrate; In methanol; at 90 ℃;

DOI:10.1002/cmdc.201700440

Reference yield: 76.0%

ethyl thiophen-2-ylacetate (57382-97-5) → 2?(thiophen?2?yl)acetohydrazide (39978-18-2)

Guidance literature:

With hydrazine hydrate; at 20 ℃;

DOI:10.1007/s13738-019-01848-3

Reference yield: 73.0%

(2-Thiophen-2-yl-acetyl)-phosphonic acid dimethyl ester (87600-60-0) → 2?(thiophen?2?yl)acetohydrazide (39978-18-2)

Guidance literature:

With hydrazine; In ethanol; at 0 - 20 ℃; for 12h;

DOI:10.1080/713744566

upstream raw materials:

ethyl thiophen-2-ylacetate

(2-Thiophen-2-yl-acetyl)-phosphonic acid dimethyl ester

(2-Thiophen-2-yl-acetyl)-phosphonic acid diisopropyl ester

2-thienylacetic acid chloride

Refernces

• 1、 Gavara, Laurent,Legru, Alice,Verdirosa, Federica,Sevaille, Laurent,Nauton, Lionel,Corsica, Giuseppina,Mercuri, Paola Sandra,Sannio, Filomena,Feller, Georges,Coulon, Rémi,De Luca, Filomena,Cerboni, Giulia,Tanfoni, Silvia,Chelini, Giulia,Galleni, Moreno,Docquier, Jean-Denis,Hernandez, Jean-Fran?ois. "4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors". supporting information. . Retrieved 2021/06/15.
• 2、 Mori, Hisashi,Wada, Ryogo,Takahara, Satoyuki,Horino, Yoshikazu,Izumi, Hironori,Ishimoto, Tetsuya,Yoshida, Tomoyuki,Mizuguchi, Mineyuki,Obita, Takayuki,Gouda, Hiroaki,Hirono, Shuichi,Toyooka, Naoki. "A novel serine racemase inhibitor suppresses neuronal over-activation in vivo". . p. 3736 - 3745. Retrieved 2017/06/13.