1-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phenyl]-3-(4-nitro-phenyl)-urea

Base Information

• Chemical Name: 1-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phenyl]-3-(4-nitro-phenyl)-urea
• CAS No.: 80258-76-0
• Molecular Formula: C₂₂H₁₆N₄O₅
• Molecular Weight: 416.393
• Mol file: 80258-76-0.mol

Synonyms:1-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phenyl]-3-(4-nitro-phenyl)-urea

Chemical Property of 1-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phenyl]-3-(4-nitro-phenyl)-urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phenyl]-3-(4-nitro-phenyl)-urea

There total 1 articles about 1-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phenyl]-3-(4-nitro-phenyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(4-amino-benzyl)-isoindole-1,3-dione (100880-61-3) + 4-Nitrophenyl isocyanate (100-28-7) → 1-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phenyl]-3-(4-nitro-phenyl)-urea (80258-76-0)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; In benzene; at 50 ℃; for 0.166667h;

DOI:10.1021/jm00345a015

Reference yield: 71.0%

1-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phenyl]-3-(4-nitro-phenyl)-urea (80258-76-0) → 1-(4-Aminomethyl-phenyl)-3-(4-nitro-phenyl)-urea (80258-82-8)

Guidance literature:

With pyridine; hydrazine hydrate; at 60 ℃; for 3h;

DOI:10.1021/jm00345a015

Reference yield:

1-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phenyl]-3-(4-nitro-phenyl)-urea (80258-76-0) → 1-(4-Aminomethyl-phenyl)-3-(4-amino-phenyl)-urea

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / hydrazine hydrate, pyridine / 3 h / 60 °C

2: Fe, HCl

With pyridine; hydrogenchloride; iron; hydrazine hydrate;

DOI:10.1021/jm00345a015

upstream raw materials:

2-(4-amino-benzyl)-isoindole-1,3-dione

4-Nitrophenyl isocyanate

Downstream raw materials:

1-(4-Aminomethyl-phenyl)-3-(4-nitro-phenyl)-urea

1-[4-(Acridin-9-ylamino)-phenyl]-3-(4-aminomethyl-phenyl)-urea; hydrochloride

1-(4-Aminomethyl-phenyl)-3-[4-(3-nitro-acridin-9-ylamino)-phenyl]-urea; hydrochloride