benzyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate

Base Information

Chemical Name:benzyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate
CAS No.:1300035-76-0
Molecular Formula:C₃₄H₄₄BrNO₅Si
Molecular Weight:654.717
Hs Code.:

Synonyms:benzyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate

Suppliers and Price of benzyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate

There total 3 articles about benzyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1300035-29-3
C₂₆H₂₆BrNO₄

: 86864-60-0
2-(tert-butyldimethylsilyloxy)ethyl bromide

: 1300035-76-0
benzyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate

Guidance literature:: C₂₆H₂₆BrNO₄; With potassium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

2-(tert-butyldimethylsilyloxy)ethyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol200725m

Reference yield:

: 1300035-74-8
(S)-1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-amine

: 1300035-76-0
benzyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.1: potassium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With pyridine; potassium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol200725m

Reference yield:

: 1300035-27-1
tert-butyl (S)-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)carbamate

: 1300035-76-0
benzyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.1: potassium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With pyridine; potassium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol200725m