1,3-Piperidinedicarboxylic acid, 3-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester

Base Information

• Chemical Name: 1,3-Piperidinedicarboxylic acid, 3-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester
• CAS No.: 959236-11-4
• Molecular Formula: C₁₄H₂₃NO₄
• Molecular Weight: 269.341
• Hs Code.: 2933399090
• Mol file: 959236-11-4.mol

Synonyms:3-allylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester;

Chemical Property of 1,3-Piperidinedicarboxylic acid, 3-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester

Chemical Property:

• PSA: 66.84000
• LogP: 2.60230

Purity/Quality:

99%, ^*data from raw suppliers

1-Boc-3-allylpiperidine-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Piperidinedicarboxylic acid, 3-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester

There total 2 articles about 1,3-Piperidinedicarboxylic acid, 3-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine-1,3-dicarboxylic acid 3-allyl ester 1-tert-butyl ester (1263773-92-7) → 3-allylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester (959236-11-4)

Guidance literature:

piperidine-1,3-dicarboxylic acid 3-allyl ester 1-tert-butyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -72 - 0 ℃; for 0.7h;

With chloro-trimethyl-silane; In tetrahydrofuran; at -67 - 2.5 ℃; for 3h;

Reference yield:

N-(tert-butyloxycarbonyl)nipecotic acid (71381-75-4,88495-54-9,84358-12-3) → 3-allylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester (959236-11-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.7 h / -72 - 0 °C

2.2: 3 h / -67 - 2.5 °C

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

3-allylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester (959236-11-4) + C18H24N2O3*C2HF3O2 → C32H45N3O6

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃; for 16h; Sealed tube;

DOI:10.1002/ejoc.202100195

upstream raw materials:

N-(tert-butyloxycarbonyl)nipecotic acid

piperidine-1,3-dicarboxylic acid 3-allyl ester 1-tert-butyl ester

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