N¹,N⁴-dibenzyl-N⁹-(tert-butoxycarbonyl)-4-aza-1,9-diaminononane

Base Information

• Chemical Name: N¹,N⁴-dibenzyl-N⁹-(tert-butoxycarbonyl)-4-aza-1,9-diaminononane
• CAS No.: 170018-89-0
• Molecular Formula: C₂₇H₄₁N₃O₂
• Molecular Weight: 439.641
• Mol file: 170018-89-0.mol

Synonyms:N¹,N⁴-dibenzyl-N⁹-(tert-butoxycarbonyl)-4-aza-1,9-diaminononane

Chemical Property of N¹,N⁴-dibenzyl-N⁹-(tert-butoxycarbonyl)-4-aza-1,9-diaminononane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹,N⁴-dibenzyl-N⁹-(tert-butoxycarbonyl)-4-aza-1,9-diaminononane

There total 9 articles about N¹,N⁴-dibenzyl-N⁹-(tert-butoxycarbonyl)-4-aza-1,9-diaminononane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-tert-butoxycarbonylamino-1-aminopentane (51644-96-3) → N1,N4-dibenzyl-N9-(tert-butoxycarbonyl)-4-aza-1,9-diaminononane (170018-89-0)

Guidance literature:

Multi-step reaction with 6 steps

1: MgSO₄ / methanol / 3 h

2: NaBH₄ / methanol / 19 h / Heating

3: 83.1 percent / 50 percent KF/Celite / acetonitrile / 15 h / Heating

4: 85.5 percent / N₂H₄ / methanol / 15 h / Heating

5: MgSO₄ / methanol

6: NaBH₄ / methanol / Heating

With potassium fluoride; sodium tetrahydroborate; Celite; magnesium sulfate; hydrazine; In methanol; acetonitrile; 1: Condensation / 2: Reduction / 3: Alkylation / 4: dephthaloylation / 5: Condensation / 6: Reduction;

DOI:10.1023/A:1011988317683

Reference yield:

N1-benzyl-N5-(tert-butoxycarbonyl)-1,5-diaminopentane (122631-98-5) → N1,N4-dibenzyl-N9-(tert-butoxycarbonyl)-4-aza-1,9-diaminononane (170018-89-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 83.1 percent / 50 percent KF/Celite / acetonitrile / 15 h / Heating

2: 85.5 percent / N₂H₄ / methanol / 15 h / Heating

3: MgSO₄ / methanol

4: NaBH₄ / methanol / Heating

With potassium fluoride; sodium tetrahydroborate; Celite; magnesium sulfate; hydrazine; In methanol; acetonitrile; 1: Alkylation / 2: dephthaloylation / 3: Condensation / 4: Reduction;

DOI:10.1023/A:1011988317683

Reference yield:

N1-benzyl-N5-(tert-butoxycarbonyl)-N1-(3-phthaloylpropyl)-1,5-diaminopentane (122631-99-6) → N1,N4-dibenzyl-N9-(tert-butoxycarbonyl)-4-aza-1,9-diaminononane (170018-89-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 85.5 percent / N₂H₄ / methanol / 15 h / Heating

2: MgSO₄ / methanol

3: NaBH₄ / methanol / Heating

With sodium tetrahydroborate; magnesium sulfate; hydrazine; In methanol; 1: dephthaloylation / 2: Condensation / 3: Reduction;

DOI:10.1023/A:1011988317683

upstream raw materials:

N⁴-benzyl-N⁹-(tert-butoxycarbonyl)-4-aza-1,9-diaminononane

benzaldehyde

5-tert-butoxycarbonylamino-1-aminopentane

N¹-benzyl-N⁵-(tert-butoxycarbonyl)-1,5-diaminopentane

Downstream raw materials:

[5-({3-[(3-Amino-propyl)-benzyl-amino]-propyl}-benzyl-amino)-pentyl]-carbamic acid tert-butyl ester

N⁶,N¹⁰-dibenzyl-N¹-(tert-butoxycarbonyl)-6,10-diaza-1,16-diaminohexadecane

N⁶,N¹⁰-dibenzyl-N¹⁶-benzyloxycarboyl-6,10-diaza-1,16-diaminohexadecane

N⁶,N¹⁰-dibenzyl-N¹⁶-benzyloxycarboyl-N¹-(tert-butoxycarbonyl)-6,10-diaza-1,16-diaminohexadecane