Technology Process of 1,3-bis(2-fluorobenzoyl)-5-bromobenzene thiosemicarbazone
There total 3 articles about 1,3-bis(2-fluorobenzoyl)-5-bromobenzene thiosemicarbazone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,3-bis(2-fluorobenzoyl)-5-bromobenzene;
With
toluene-4-sulfonic acid;
In
tetrahydrofuran;
for 0.166667h;
Reflux;
thiosemicarbazide;
In
tetrahydrofuran;
for 28h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tert.-butyl lithium / pentane; diethyl ether / -78 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: toluene-4-sulfonic acid / tetrahydrofuran / 0.17 h / Reflux
2.2: 28 h / Inert atmosphere
With
tert.-butyl lithium; toluene-4-sulfonic acid;
In
tetrahydrofuran; diethyl ether; pentane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 0.17 h / 0 °C
1.2: 0 - 20 °C
2.1: tert.-butyl lithium / pentane; diethyl ether / -78 °C / Inert atmosphere
2.2: -78 - 20 °C
3.1: toluene-4-sulfonic acid / tetrahydrofuran / 0.17 h / Reflux
3.2: 28 h / Inert atmosphere
With
tert.-butyl lithium; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane; pentane;
