2,3-difluoro-6-methoxybenzyl alcohol

Base Information

• Chemical Name: 2,3-difluoro-6-methoxybenzyl alcohol
• CAS No.: 773871-99-1
• Molecular Formula: C₈H₈F₂O₂
• Molecular Weight: 174.147
• Hs Code.: 2909498090
• Mol file: 773871-99-1.mol

Synonyms:2,3-difluoro-6-methoxybenzyl alcohol

Chemical Property of 2,3-difluoro-6-methoxybenzyl alcohol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2,3-Difluoro-6-methoxybenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-difluoro-6-methoxybenzyl alcohol

There total 1 articles about 2,3-difluoro-6-methoxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-difluoro-6-methoxybenzaldehyde (187543-87-9) → 2,3-difluoro-6-methoxybenzyl alcohol (773871-99-1)

Guidance literature:

With sodium tetrahydroborate; sodium hydroxide; In water; toluene; at 35 - 39 ℃; for 5h;

Reference yield:

2,3-difluoro-6-methoxybenzyl alcohol (773871-99-1) → 3-(chloromethyl)-1,2-difluoro-4-methoxybenzene (1073435-67-2)

Guidance literature:

With thionyl chloride; In toluene; at 20 ℃;

Reference yield:

2,3-difluoro-6-methoxybenzyl alcohol (773871-99-1) → 3-[2-fluoro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenyl]-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,4- d]pyrimidine-5-carboxylic acid (2-hydroxyethyl)trimethylammonium (1321816-57-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: hydrogenchloride / toluene; water / 5 h / 38 - 43 °C

2.1: sodium hydroxide; tetrabutylammomium bromide / toluene; water / 4 h / 60 - 63 °C

3.1: acetic acid; nitric acid / 2 h / 59 - 62 °C

4.1: hydrogen / ethyl acetate / 4 h / 20 °C

5.1: triethylamine / tetrahydrofuran / 24 h / 20 °C

6.1: lithium hydroxide / tetrahydrofuran; methanol; water / 1.5 h / 11 - 13 °C

7.1: diisopropylamine / methanol; water / 0.17 h / 20 °C

7.2: 5 h / 40 - 60 °C / Cooling with ice

With hydrogenchloride; tetrabutylammomium bromide; hydrogen; nitric acid; acetic acid; triethylamine; diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; water; ethyl acetate; toluene;

upstream raw materials:

2,3-difluoro-6-methoxybenzaldehyde

Downstream raw materials:

3-(chloromethyl)-1,2-difluoro-4-methoxybenzene

1,2-difluoro-3-[(4-fluoro-2-methoxyphenoxy)methyl]-4-methoxybenzene

1,2-difluoro-3-[(4-fluoro-2-methoxy-5-nitrophenoxy)methyl]-4-methoxybenzene

2-fluoro-5-[(2,3-difluoro-6-methoxyphenyl)methoxy]-4-methoxyaniline