{1-[6-(4-benzyloxy-2-fluorophenyl)-3-methyl-1-(tetrahydropyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-4-phenylpiperidin-4-yl}carbamic acid tert-butyl ester

Base Information

Chemical Name:{1-[6-(4-benzyloxy-2-fluorophenyl)-3-methyl-1-(tetrahydropyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-4-phenylpiperidin-4-yl}carbamic acid tert-butyl ester
CAS No.:1429171-74-3
Molecular Formula:C₄₂H₄₆FN₅O₅
Molecular Weight:719.856
Hs Code.:

{1-[6-(4-benzyloxy-2-fluorophenyl)-3-methyl-1-(tetrahydropyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-4-phenylpiperidin-4-yl}carbamic acid tert-butyl ester

Synonyms:{1-[6-(4-benzyloxy-2-fluorophenyl)-3-methyl-1-(tetrahydropyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-4-phenylpiperidin-4-yl}carbamic acid tert-butyl ester

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Chemical Property of {1-[6-(4-benzyloxy-2-fluorophenyl)-3-methyl-1-(tetrahydropyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-4-phenylpiperidin-4-yl}carbamic acid tert-butyl ester

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Technology Process of {1-[6-(4-benzyloxy-2-fluorophenyl)-3-methyl-1-(tetrahydropyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-4-phenylpiperidin-4-yl}carbamic acid tert-butyl ester

There total 5 articles about {1-[6-(4-benzyloxy-2-fluorophenyl)-3-methyl-1-(tetrahydropyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-4-phenylpiperidin-4-yl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1429171-72-1
6-(4-benzyloxy-2-fluorophenyl)-3-methyl-1-(tetrahydropyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

: 178914-47-1
4-tert-butoxycarbonylamino-4-phenylpiperidine

: 1429171-74-3
{1-[6-(4-benzyloxy-2-fluorophenyl)-3-methyl-1-(tetrahydropyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-4-phenylpiperidin-4-yl}carbamic acid tert-butyl ester

Guidance literature:: With 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 120h;

Reference yield:

: 1429171-71-0
6-bromo-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid ethyl ester

: 1429171-74-3
{1-[6-(4-benzyloxy-2-fluorophenyl)-3-methyl-1-(tetrahydropyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-4-phenylpiperidin-4-yl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 1.5 h / 85 °C / Inert atmosphere

2: sodium hydroxide; water / isopropyl alcohol

3: 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 120 h / 20 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; water; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,2-dimethoxyethane; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 1429171-73-2
6-(4-benzyloxy-2-fluorophenyl)-3-methyl-1-(tetrahydropyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid ethyl ester

: 1429171-74-3
{1-[6-(4-benzyloxy-2-fluorophenyl)-3-methyl-1-(tetrahydropyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-4-phenylpiperidin-4-yl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / isopropyl alcohol

2: 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 120 h / 20 °C

With water; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; isopropyl alcohol;