2-{4-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-phenyl}-N-(4-hydrazinocarbonylmethyl-phenyl)-acetamide

Base Information

Chemical Name:2-{4-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-phenyl}-N-(4-hydrazinocarbonylmethyl-phenyl)-acetamide
CAS No.:96760-68-8
Molecular Formula:C₂₆H₂₈N₈O₆
Molecular Weight:548.558
Hs Code.:

2-{4-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-phenyl}-N-(4-hydrazinocarbonylmethyl-phenyl)-acetamide

Synonyms:2-{4-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-phenyl}-N-(4-hydrazinocarbonylmethyl-phenyl)-acetamide

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Chemical Property of 2-{4-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-phenyl}-N-(4-hydrazinocarbonylmethyl-phenyl)-acetamide

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Technology Process of 2-{4-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-phenyl}-N-(4-hydrazinocarbonylmethyl-phenyl)-acetamide

There total 5 articles about 2-{4-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-phenyl}-N-(4-hydrazinocarbonylmethyl-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 96760-66-6
N⁶-<4-<<<<4-<<(Methyloxy)carbonyl>methyl>phenyl>amino>carbonyl>methyl>phenyl>adenosine

: 96760-68-8
2-{4-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-phenyl}-N-(4-hydrazinocarbonylmethyl-phenyl)-acetamide

Guidance literature:: With hydrazine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00147a038

Reference yield:

: 1197-55-3
4-aminophenylacetic acid

: 96760-68-8
2-{4-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-phenyl}-N-(4-hydrazinocarbonylmethyl-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / HCl gas / 4 h

2: 66 percent / EDAC, 1-hydroxybenzotriazole, N-ethylmorpholine / dimethylformamide / 2 h / Ambient temperature

3: 68 percent / NH₂NH₂ / dimethylformamide

With N-ethylmorpholine;; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydrazine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00147a038

Reference yield:

: 2004-06-0
6-Chloropurine riboside

: 96760-68-8
2-{4-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-phenyl}-N-(4-hydrazinocarbonylmethyl-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / triethylamine / ethanol; H₂O / 72 h / 80 °C

2: 66 percent / EDAC, 1-hydroxybenzotriazole, N-ethylmorpholine / dimethylformamide / 2 h / Ambient temperature

3: 68 percent / NH₂NH₂ / dimethylformamide

With N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; hydrazine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00147a038