5-(4-tert-butylphenyl)-7-bromo-8-(trifluoromethanesulfonyloxy)quinoline

Base Information

Chemical Name:5-(4-tert-butylphenyl)-7-bromo-8-(trifluoromethanesulfonyloxy)quinoline
CAS No.:1346013-38-4
Molecular Formula:C₂₀H₁₇BrF₃NO₃S
Molecular Weight:488.325
Hs Code.:

Synonyms:5-(4-tert-butylphenyl)-7-bromo-8-(trifluoromethanesulfonyloxy)quinoline

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Chemical Property of 5-(4-tert-butylphenyl)-7-bromo-8-(trifluoromethanesulfonyloxy)quinoline

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Technology Process of 5-(4-tert-butylphenyl)-7-bromo-8-(trifluoromethanesulfonyloxy)quinoline

There total 2 articles about 5-(4-tert-butylphenyl)-7-bromo-8-(trifluoromethanesulfonyloxy)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1346013-06-6
5,7-dibromo-8-(trifluoromethanesulfonyloxy)quinoline

: 123324-71-0
p-tert-butylphenylboronic acid

: 1346013-38-4
5-(4-tert-butylphenyl)-7-bromo-8-(trifluoromethanesulfonyloxy)quinoline

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 90 ℃; for 8h; regioselective reaction; Inert atmosphere;
DOI:10.1002/adsc.201100165

Reference yield:

: 521-74-4
broxyquinoline

: 1346013-38-4
5-(4-tert-butylphenyl)-7-bromo-8-(trifluoromethanesulfonyloxy)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 0.17 h / -78 °C / Inert atmosphere

1.2: 4 h / -78 - 0 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 8 h / 90 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; dichloromethane; 2.1: Suzuki-Miyaura reaction;
DOI:10.1002/adsc.201100165