methyl 2-((3S)-6-((1R)-7-fluoro-4-(3-fluoro-2-(1-methyl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

Base Information

Chemical Name:methyl 2-((3S)-6-((1R)-7-fluoro-4-(3-fluoro-2-(1-methyl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate
CAS No.:1458655-84-9
Molecular Formula:C₂₈H₂₄F₂N₄O₄
Molecular Weight:518.52
Hs Code.:

Synonyms:methyl 2-((3S)-6-((1R)-7-fluoro-4-(3-fluoro-2-(1-methyl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

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Chemical Property of methyl 2-((3S)-6-((1R)-7-fluoro-4-(3-fluoro-2-(1-methyl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

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Technology Process of methyl 2-((3S)-6-((1R)-7-fluoro-4-(3-fluoro-2-(1-methyl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

There total 6 articles about methyl 2-((3S)-6-((1R)-7-fluoro-4-(3-fluoro-2-(1-methyl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 925215-02-7
5-(2-fluoro-6-iodophenyl)-1-methyl-1H-tetrazole

: 1458652-59-9
methyl 2-((S)-6-((R)-7-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

: 1458655-84-9
methyl 2-((3S)-6-((1R)-7-fluoro-4-(3-fluoro-2-(1-methyl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

Guidance literature:: With potassium phosphate; dichloro(1,3-bis(2,6-bis(3-pentyl)phenyl)imidazolin-2-ylidene)(3-chloropyridyl)palladium(II); In 1,4-dioxane; at 100 ℃; for 12h; Inert atmosphere; Sealed tube;

Reference yield:

: 578729-17-6
5-(2-fluoro-6-iodophenyl)-2H-tetrazole

: 1458655-84-9
methyl 2-((3S)-6-((1R)-7-fluoro-4-(3-fluoro-2-(1-methyl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: potassium phosphate; dichloro(1,3-bis(2,6-bis(3-pentyl)phenyl)imidazolin-2-ylidene)(3-chloropyridyl)palladium(II) / 1,4-dioxane / 12 h / 100 °C / Inert atmosphere; Sealed tube

With potassium phosphate; dichloro(1,3-bis(2,6-bis(3-pentyl)phenyl)imidazolin-2-ylidene)(3-chloropyridyl)palladium(II); potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 79544-29-9
2-fluoro-6-iodobenzonitrile

: 1458655-84-9
methyl 2-((3S)-6-((1R)-7-fluoro-4-(3-fluoro-2-(1-methyl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: azido tributyltin (IV) / 72 h / 125 °C / Sealed tube

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: potassium phosphate; dichloro(1,3-bis(2,6-bis(3-pentyl)phenyl)imidazolin-2-ylidene)(3-chloropyridyl)palladium(II) / 1,4-dioxane / 12 h / 100 °C / Inert atmosphere; Sealed tube

With potassium phosphate; dichloro(1,3-bis(2,6-bis(3-pentyl)phenyl)imidazolin-2-ylidene)(3-chloropyridyl)palladium(II); potassium carbonate; azido tributyltin (IV); In 1,4-dioxane; N,N-dimethyl-formamide;