2-Dihydroxy-2-(3,4-dimethoxybenzyl)-6-methoxy-3,4-dihydro-(2H)-naphthalin

Base Information

• Chemical Name: 2-Dihydroxy-2-(3,4-dimethoxybenzyl)-6-methoxy-3,4-dihydro-(2H)-naphthalin
• CAS No.: 161873-00-3
• Molecular Formula: C₂₀H₂₄O₅
• Molecular Weight: 344.408
• Mol file: 161873-00-3.mol

Synonyms:2-Dihydroxy-2-(3,4-dimethoxybenzyl)-6-methoxy-3,4-dihydro-(2H)-naphthalin

Chemical Property of 2-Dihydroxy-2-(3,4-dimethoxybenzyl)-6-methoxy-3,4-dihydro-(2H)-naphthalin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Dihydroxy-2-(3,4-dimethoxybenzyl)-6-methoxy-3,4-dihydro-(2H)-naphthalin

There total 3 articles about 2-Dihydroxy-2-(3,4-dimethoxybenzyl)-6-methoxy-3,4-dihydro-(2H)-naphthalin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Spiro<3'-(3,4-dimethoxyphenyl)-1-hydroxy-6-methoxy-1,2,3,4-tetrahydronaphthalin-2,2'-oxiran> (161873-02-5) → 2-Dihydroxy-2-(3,4-dimethoxybenzyl)-6-methoxy-3,4-dihydro-(2H)-naphthalin (161873-00-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Heating;

DOI:10.1002/prac.19953370111

Reference yield:

2-<(3,4-Dimethoxyphenyl)-methylen>-6-methoxy-(2H)-3,4-dihydronaphthalin-1-on (149862-20-4) → 2-Dihydroxy-2-(3,4-dimethoxybenzyl)-6-methoxy-3,4-dihydro-(2H)-naphthalin (161873-00-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / NaOH, H₂O₂ / dioxane / 70 °C

2: 71 percent / NaBH₄ / H₂O; dioxane / 1.5 h

3: 95 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; dihydrogen peroxide; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1002/prac.19953370111

Reference yield:

Spiro-<3'-(3,4-dimethoxyphenyl)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalin-2,2'-oxiran> (161872-98-6) → 2-Dihydroxy-2-(3,4-dimethoxybenzyl)-6-methoxy-3,4-dihydro-(2H)-naphthalin (161873-00-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / NaBH₄ / H₂O; dioxane / 1.5 h

2: 95 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

With sodium tetrahydroborate; lithium aluminium tetrahydride; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1002/prac.19953370111

upstream raw materials:

Spiro<3'-(3,4-dimethoxyphenyl)-1-hydroxy-6-methoxy-1,2,3,4-tetrahydronaphthalin-2,2'-oxiran>

2-<(3,4-Dimethoxyphenyl)-methylen>-6-methoxy-(2H)-3,4-dihydronaphthalin-1-on

Spiro-<3'-(3,4-dimethoxyphenyl)-6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalin-2,2'-oxiran>