[1-Benzyl-4-(3-methoxy-2-vinyl-benzyl)-pyrrolidin-(3Z)-ylidene]-[(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-amine

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Chemical Name:[1-Benzyl-4-(3-methoxy-2-vinyl-benzyl)-pyrrolidin-(3Z)-ylidene]-[(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-amine
CAS No.:479197-63-2
Molecular Formula:C₂₉H₃₉N₃O₂
Molecular Weight:461.648
Hs Code.:

Synonyms:[1-Benzyl-4-(3-methoxy-2-vinyl-benzyl)-pyrrolidin-(3Z)-ylidene]-[(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-amine

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Chemical Property of [1-Benzyl-4-(3-methoxy-2-vinyl-benzyl)-pyrrolidin-(3Z)-ylidene]-[(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-amine

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Technology Process of [1-Benzyl-4-(3-methoxy-2-vinyl-benzyl)-pyrrolidin-(3Z)-ylidene]-[(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-amine

There total 5 articles about [1-Benzyl-4-(3-methoxy-2-vinyl-benzyl)-pyrrolidin-(3Z)-ylidene]-[(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 479197-59-6
1-bromomethyl-3-methoxy-2-vinyl-benzene

: 479197-60-9
[1-Benzyl-pyrrolidin-(3E)-ylidene]-[(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-amine

: 479197-63-2
[1-Benzyl-4-(3-methoxy-2-vinyl-benzyl)-pyrrolidin-(3Z)-ylidene]-[(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-amine

: [1-Benzyl-2-(3-methoxy-2-vinyl-benzyl)-pyrrolidin-(3E)-ylidene]-[(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-amine

Guidance literature:: [1-Benzyl-pyrrolidin-(3E)-ylidene]-[(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-amine; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 6h;

1-bromomethyl-3-methoxy-2-vinyl-benzene; In tetrahydrofuran; at -100 - 20 ℃; for 12h;
DOI:10.1055/s-2002-34224

Reference yield:

: 775-16-6
N-benzyl-3-pyrrolidinone

: 479197-63-2
[1-Benzyl-4-(3-methoxy-2-vinyl-benzyl)-pyrrolidin-(3Z)-ylidene]-[(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Na₂SO₄ / CH₂Cl₂ / 20 °C

2.1: LHMDS / tetrahydrofuran / 6 h / 0 °C

2.2: tetrahydrofuran / 12 h / -100 - 20 °C

With sodium sulfate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 2.2: Ender's alkylation;
DOI:10.1055/s-2002-34224

Reference yield:

: 64957-80-8
3-methoxy-2-vinylbenzoic acid

: 479197-63-2
[1-Benzyl-4-(3-methoxy-2-vinyl-benzyl)-pyrrolidin-(3Z)-ylidene]-[(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / LiAlH₄ / diethyl ether / 3 h / 0 - 20 °C

2.1: 90 percent / PBr₃; pyridine / CH₂Cl₂ / 2 h / 0 - 20 °C

3.1: LHMDS / tetrahydrofuran / 6 h / 0 °C

3.2: tetrahydrofuran / 12 h / -100 - 20 °C

With pyridine; lithium aluminium tetrahydride; phosphorus tribromide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane; 3.2: Ender's alkylation;
DOI:10.1055/s-2002-34224