12-O-(3-(5-(4-fluorophenyl-carbamoyl)-pyridin-2-amino)-propyl)-berbamine

Base Information

Chemical Name:12-O-(3-(5-(4-fluorophenyl-carbamoyl)-pyridin-2-amino)-propyl)-berbamine
CAS No.:1363333-04-3
Molecular Formula:C₅₂H₅₄FN₅O₇
Molecular Weight:880.028
Hs Code.:

Synonyms:12-O-(3-(5-(4-fluorophenyl-carbamoyl)-pyridin-2-amino)-propyl)-berbamine

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Chemical Property of 12-O-(3-(5-(4-fluorophenyl-carbamoyl)-pyridin-2-amino)-propyl)-berbamine

Chemical Property:

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Technology Process of 12-O-(3-(5-(4-fluorophenyl-carbamoyl)-pyridin-2-amino)-propyl)-berbamine

There total 4 articles about 12-O-(3-(5-(4-fluorophenyl-carbamoyl)-pyridin-2-amino)-propyl)-berbamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.9%

: 1256550-97-6
C₄₀H₄₇N₃O₆

: 364078-28-4
N-(4-fluoro-phenyl)-6-chloro-nicotinamide

: 1363333-04-3
12-O-(3-(5-(4-fluorophenyl-carbamoyl)-pyridin-2-amino)-propyl)-berbamine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 110 ℃;

Reference yield:

: 6078-17-7,26137-46-2,69475-26-9
berbamine dihydrochloride

: 1363333-04-3
12-O-(3-(5-(4-fluorophenyl-carbamoyl)-pyridin-2-amino)-propyl)-berbamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 110 °C

With hydrogenchloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: 1363333-04-3
12-O-(3-(5-(4-fluorophenyl-carbamoyl)-pyridin-2-amino)-propyl)-berbamine

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / Reflux

2: dichloromethane / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / 110 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;