methyl 2-methyl-3-oxo-3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate

Base Information

• Chemical Name: methyl 2-methyl-3-oxo-3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate
• CAS No.: 1361979-10-3
• Molecular Formula: C₁₉H₁₇N₃O₃
• Molecular Weight: 335.362
• Mol file: 1361979-10-3.mol

Synonyms:methyl 2-methyl-3-oxo-3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate

Chemical Property of methyl 2-methyl-3-oxo-3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-methyl-3-oxo-3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate

There total 2 articles about methyl 2-methyl-3-oxo-3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 2-azido-2-methyl-3-oxo-3-phenylpropanoate (1361978-88-2) + phenylacetylene (536-74-3) → methyl 2-methyl-3-oxo-3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate (1361979-10-3)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In water; tert-butyl alcohol; at 20 ℃; for 3h;

DOI:10.1002/chem.201102680

Reference yield:

methyl 2-benzoylpropionate (32742-19-1,116782-25-3,29540-54-3) → methyl 2-methyl-3-oxo-3-phenyl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate (1361979-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide; potassium 1-hydroxy-1,3-dioxo-1,3-dihydro-1λ(5)-benziodoxol-5-sulfonate; sodium iodide / water; dimethyl sulfoxide / 0.5 h / 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine / water; tert-butyl alcohol / 3 h / 20 °C

With sodium azide; copper(ll) sulfate pentahydrate; potassium 1-hydroxy-1,3-dioxo-1,3-dihydro-1λ(5)-benziodoxol-5-sulfonate; sodium L-ascorbate; sodium iodide; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In water; dimethyl sulfoxide; tert-butyl alcohol;

DOI:10.1002/chem.201102680

upstream raw materials:

methyl 2-azido-2-methyl-3-oxo-3-phenylpropanoate

phenylacetylene

methyl 2-benzoylpropionate