1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-hydroxy-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one

Base Information

Chemical Name:1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-hydroxy-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one
CAS No.:1422434-14-7
Molecular Formula:C₂₂H₂₁Cl₂N₅O₂
Molecular Weight:458.347
Hs Code.:

Synonyms:1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-hydroxy-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one

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Chemical Property of 1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-hydroxy-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one

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Technology Process of 1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-hydroxy-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one

There total 6 articles about 1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-hydroxy-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.7%

: 1422434-00-1
C₂₇H₂₈BrCl₂N₅O₃

: 1422434-14-7
1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-hydroxy-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one

Guidance literature:: C₂₇H₂₈BrCl₂N₅O₃; With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 6h;

With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1422434-42-1
C₂₇H₂₉Cl₂N₅O₄

: 1422434-14-7
1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-hydroxy-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1039/c2ob26710a

Reference yield:

: 1223081-81-9
5-bromo-8-(((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)amino)-1,6-naphthyridine-7-carboxylic acid

: 1422434-14-7
1-((1r,4r)-4-aminocyclohexyl)-3-(3,4-dichlorobenzyl)-5-hydroxy-1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)one

Guidance literature:: Multi-step reaction with 4 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 90 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: water; potassium carbonate / N,N-dimethyl-formamide / Heating

4: trifluoroacetic acid / dichloromethane / 20 °C

With diphenyl phosphoryl azide; water; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c2ob26710a