5'-O-(4,4'-dimethoxytrityl)-3'-O-(methyl phosphor-N,N-diisopropylamidite)-α,α,α-trifluorothymidine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-3'-O-(methyl phosphor-N,N-diisopropylamidite)-α,α,α-trifluorothymidine
• CAS No.: 133100-90-0
• Molecular Formula: C₃₈H₄₅F₃N₃O₉P
• Molecular Weight: 775.759

Synonyms:5'-O-(4,4'-dimethoxytrityl)-3'-O-(methyl phosphor-N,N-diisopropylamidite)-α,α,α-trifluorothymidine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-3'-O-(methyl phosphor-N,N-diisopropylamidite)-α,α,α-trifluorothymidine

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-3'-O-(methyl phosphor-N,N-diisopropylamidite)-α,α,α-trifluorothymidine

There total 3 articles about 5'-O-(4,4'-dimethoxytrityl)-3'-O-(methyl phosphor-N,N-diisopropylamidite)-α,α,α-trifluorothymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N,N-diisopropylmethylphosphonamidic chloride (125348-17-6) + 5'-O-(4,4'-dimethoxytrityl)-α,α,α-trifluorothymidine (133128-06-0) → 5'-O-(4,4'-dimethoxytrityl)-3'-O-(methyl phosphor-N,N-diisopropylamidite)-α,α,α-trifluorothymidine (133100-90-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In chloroform; for 4h; Ambient temperature;

DOI:10.1021/jo00011a028

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 5'-O-(4,4'-dimethoxytrityl)-3'-O-(methyl phosphor-N,N-diisopropylamidite)-α,α,α-trifluorothymidine (133100-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: 74 percent / diisopropylethylamin / CHCl₃ / 4 h / Ambient temperature

With pyridine; N-ethyl-N,N-diisopropylamine; In chloroform;

DOI:10.1021/jo00011a028

Reference yield:

2'-deoxy-5-trifluoromethyluridine (70-00-8) → 5'-O-(4,4'-dimethoxytrityl)-3'-O-(methyl phosphor-N,N-diisopropylamidite)-α,α,α-trifluorothymidine (133100-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: 74 percent / diisopropylethylamin / CHCl₃ / 4 h / Ambient temperature

With pyridine; N-ethyl-N,N-diisopropylamine; In chloroform;

DOI:10.1021/jo00011a028

upstream raw materials:

N,N-diisopropylmethylphosphonamidic chloride

5'-O-(4,4'-dimethoxytrityl)-α,α,α-trifluorothymidine

4,4'-dimethoxytrityl chloride

2'-deoxy-5-trifluoromethyluridine

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