cyclohexanecarboxylic acid [3-fluoro-4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-amide

Base Information

• Chemical Name: cyclohexanecarboxylic acid [3-fluoro-4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-amide
• CAS No.: 1027300-90-8
• Molecular Formula: C₂₀H₁₉FN₄O₃
• Molecular Weight: 382.394

Synonyms:cyclohexanecarboxylic acid [3-fluoro-4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-amide

Chemical Property of cyclohexanecarboxylic acid [3-fluoro-4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-amide

Chemical Property:

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Technology Process of cyclohexanecarboxylic acid [3-fluoro-4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-amide

There total 3 articles about cyclohexanecarboxylic acid [3-fluoro-4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-4-aminobenzoic acid (446-31-1) → cyclohexanecarboxylic acid [3-fluoro-4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-amide (1027300-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: polyphosphoric acid / xylene / 60 - 150 °C

2: pyridine / 3 h / 20 °C

With pyridine; PPA; In xylene;

DOI:10.1016/j.ejmech.2006.03.014

Reference yield:

4-Nitrophenylene-1,2-diamine (99-56-9) → cyclohexanecarboxylic acid [3-fluoro-4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-amide (1027300-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: polyphosphoric acid / xylene / 60 - 150 °C

2: pyridine / 3 h / 20 °C

With pyridine; PPA; In xylene;

DOI:10.1016/j.ejmech.2006.03.014

Reference yield:

3-fluoro-4-(5-nitro-1H-benzoimidazol-2-yl)-phenylamine (1026305-64-5) + cyclohexanylcarbonyl chloride (2719-27-9) → cyclohexanecarboxylic acid [3-fluoro-4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-amide (1027300-90-8)

Guidance literature:

With pyridine; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2006.03.014

upstream raw materials:

3-fluoro-4-(5-nitro-1H-benzoimidazol-2-yl)-phenylamine

cyclohexanylcarbonyl chloride

2-fluoro-4-aminobenzoic acid

4-Nitrophenylene-1,2-diamine

Downstream raw materials:

cyclohexanecarboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-3-fluoro-phenyl]-amide

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