2,6-bis[(S)-4'-isopropyloxazolin-2'yl]-4-(4-isopropylthio)-1-phenoxypyridine

Base Information

• Chemical Name: 2,6-bis[(S)-4'-isopropyloxazolin-2'yl]-4-(4-isopropylthio)-1-phenoxypyridine
• CAS No.: 1061212-99-4
• Molecular Formula: C₂₆H₃₃N₃O₃S
• Molecular Weight: 467.632
• Mol file: 1061212-99-4.mol

Synonyms:2,6-bis[(S)-4'-isopropyloxazolin-2'yl]-4-(4-isopropylthio)-1-phenoxypyridine

Chemical Property of 2,6-bis[(S)-4'-isopropyloxazolin-2'yl]-4-(4-isopropylthio)-1-phenoxypyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-bis[(S)-4'-isopropyloxazolin-2'yl]-4-(4-isopropylthio)-1-phenoxypyridine

There total 2 articles about 2,6-bis[(S)-4'-isopropyloxazolin-2'yl]-4-(4-isopropylthio)-1-phenoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-isopropyl-thiophenol (70551-46-1) + (4S,4'S)-2,2'-(4-chloropyridine-2,6-diyl)bis(4-isopropyl-4,4-dihydrooxazole) (142611-36-7) → 2,6-bis[(S)-4'-isopropyloxazolin-2'yl]-4-(4-isopropylthio)-1-phenoxypyridine (1061212-99-4)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 80 ℃;

DOI:10.1016/j.tetlet.2008.06.075

Reference yield:

1-methoxy-4-<(1-methylethyl)thio>-benzene (7205-61-0) → 2,6-bis[(S)-4'-isopropyloxazolin-2'yl]-4-(4-isopropylthio)-1-phenoxypyridine (1061212-99-4)

Guidance literature:

Multi-step reaction with 2 steps

1: boron tribromide

2: caesium carbonate / dimethyl sulfoxide / 80 °C

With boron tribromide; caesium carbonate; In dimethyl sulfoxide;

DOI:10.1002/ejoc.201200416

Reference yield: 56.0%

rhodium(III) chloride + 2,6-bis[(S)-4'-isopropyloxazolin-2'yl]-4-(4-isopropylthio)-1-phenoxypyridine (1061212-99-4) → 2,6-bis[(S)-4'-isopropyloxazolin-2'yl]-4-(4-isopropylthio)-1-phenoxypyridine rhodium chloride

Guidance literature:

In ethanol; dimethyl sulfoxide; at 80 ℃; for 24h;

DOI:10.1002/ejoc.201200416

upstream raw materials:

4-isopropyl-thiophenol

(4S,4'S)-2,2'-(4-chloropyridine-2,6-diyl)bis(4-isopropyl-4,4-dihydrooxazole)

1-methoxy-4-<(1-methylethyl)thio>-benzene