(R)-3-Benzyloxypyrrolidine hydrochloride

Base Information

• Chemical Name: (R)-3-Benzyloxypyrrolidine hydrochloride
• CAS No.: 927819-90-7
• Molecular Formula: C11H15 N O . Cl H
• Molecular Weight: 213.707
• Hs Code.: 2933998090
• DSSTox Substance ID: DTXSID10581517
• Mol file: 927819-90-7.mol

Synonyms:927819-90-7;(R)-3-Benzyloxypyrrolidine hydrochloride;(R)-3-BENZYLOXY-PYRROLIDINE HYDROCHLORIDE;(R)-3-(Benzyloxy)pyrrolidine Hydrochloride;(3R)-3-benzyloxypyrrolidine hydrochloride;(R)-3-Benzyloxypyrrolidine HCl;(3R)-3-phenylmethoxypyrrolidine;hydrochloride;C11H16ClNO;(R)-3-Benzyloxy-pyrrolidine, HCl;MFCD09261313;(R)-3-BENZYLOXY-PYRROLIDINE HCL;(R)-3-Benzyloxypyrrolidinehydrochloride;SCHEMBL2175073;DTXSID10581517;HIPRPABXTKKPPY-RFVHGSKJSA-N;AKOS015920474;CS-W003604;AS-36354;(3R)-3-(Benzyloxy)pyrrolidine--hydrogen chloride (1/1)

Chemical Property of (R)-3-Benzyloxypyrrolidine hydrochloride

Chemical Property:

• Vapor Pressure: 0.000639mmHg at 25°C
• Boiling Point: 304.7°C at 760 mmHg
• Flash Point: 138.1°C
• PSA: 21.26000
• LogP: 2.69590
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 213.0920418
• Heavy Atom Count: 14
• Complexity: 143

Purity/Quality:

99% ^*data from raw suppliers

(R)-3-BENZYLOXY-PYRROLIDINEHYDROCHLORIDE ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCC1OCC2=CC=CC=C2.Cl
• Isomeric SMILES: C1CNC[C@@H]1OCC2=CC=CC=C2.Cl

Technology Process of (R)-3-Benzyloxypyrrolidine hydrochloride

There total 3 articles about (R)-3-Benzyloxypyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(3R)-N-(tert-butyloxycarbonyl)-3-(benzyloxy)pyrrolidine (177947-67-0) → (R)-3-(benzyloxy)pyrrolidine hydrochloride (927819-90-7,127342-06-7)

Guidance literature:

With hydrogenchloride; water; In dimethyl sulfoxide; at 45 - 55 ℃; for 3h; Product distribution / selectivity;

Reference yield: 85.0%

→ (R)-3-(benzyloxy)pyrrolidine hydrochloride (927819-90-7,127342-06-7)

Guidance literature:

In tert-butyl methyl ether; isopropyl alcohol; at 24 - 40 ℃; Purification / work up;

Reference yield: 75.5%

(3R)-N(H)-3-(benzyloxy)pyrrolidine (177948-70-8) → (R)-3-(benzyloxy)pyrrolidine hydrochloride (927819-90-7,127342-06-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; toluene; at 0 - 50 ℃; for 1h; Product distribution / selectivity; reduced pressure;

upstream raw materials:

(3R)-N-(tert-butyloxycarbonyl)-3-(benzyloxy)pyrrolidine

(3R)-N(H)-3-(benzyloxy)pyrrolidine

Downstream raw materials:

(3R)-N(H)-3-(benzyloxy)pyrrolidine

Refernces

• 1、 -. "PROCESS FOR PRODUCTION OF ARALKYLOXYPYRROLIDINE DERIVATIVE". Page/Page column 15. . Retrieved 2008/12/07.