3,6-Dichloro-4,5-dimethylpyridazine

Base Information

• Chemical Name: 3,6-Dichloro-4,5-dimethylpyridazine
• CAS No.: 34584-69-5
• Molecular Formula: C6H6Cl2N2
• Molecular Weight: 177.033
• Hs Code.: 2933990090
• Mol file: 34584-69-5.mol

Synonyms:3,6-dichloro-4,5-dimethyl-pyridazine;3,6-Dichlor-4,5-dimethyl-pyridazin;4,5-dimethyl-3,6-dichloropyridazine;

Chemical Property of 3,6-Dichloro-4,5-dimethylpyridazine

Chemical Property:

• Vapor Pressure: 0.000728mmHg at 25°C
• Melting Point: 120-121 °C
• Refractive Index: 1.545
• Boiling Point: 317.165 °C at 760 mmHg
• PKA: 0.29±0.10(Predicted)
• Flash Point: 174.99 °C
• PSA: 25.78000
• Density: 1.338 g/cm³
• LogP: 2.40020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3,6-Dichloro-4,5-dimethylpyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,6-Dichloro-4,5-dimethylpyridazine is a heterocyclic organic compound and can be used as a pharmaceutical intermediate.

Technology Process of 3,6-Dichloro-4,5-dimethylpyridazine

There total 7 articles about 3,6-Dichloro-4,5-dimethylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

6-hydroxy-4,5-dimethylpyridazin-3-one (5754-17-6) → 3,6-dichloro-4,5-dimethylpyridazine (34584-69-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; at 160 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

4,5-dimethyl-1,2-dihydro-pyridazine-3,6-dione (5754-17-6) → 3,6-dichloro-4,5-dimethylpyridazine (34584-69-5)

Guidance literature:

With trichlorophosphate;

DOI:10.1021/jo01124a003 DOI:10.1021/ja01646a050

Reference yield:

2,3-Dimethylmaleic anhydride (766-39-2) → 3,6-dichloro-4,5-dimethylpyridazine (34584-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrazine dihydrochloride / 3 h / 100 °C / Inert atmosphere; Reflux

2.1: trichlorophosphate / 2 h / 80 °C / Inert atmosphere

2.2: pH 10 / Cooling with ice

With hydrazine dihydrochloride; trichlorophosphate;

upstream raw materials:

4,5-dimethyl-1,2-dihydro-pyridazine-3,6-dione

1-amino-3,4-dimethyl-pyrrole-2,5-dione

6-hydroxy-4,5-dimethylpyridazin-3-one

2,3-Dimethylmaleic anhydride

Downstream raw materials:

3-amino-6-chloro-4,5-dimethylpyridazine

6-chloro-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-7,8-dimethyl-imidazo[1,2-b]pyridazine

3-chloro-4,5-dimethyl-6-((R)-3-methyl-piperazin-1-yl)-pyridazine

3-Chloro-4,5-dimethyl-6-[(R)-3-methyl-4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyridazine