(+)-(1'E,10'S)-2,4-dimethoxy-6-<10'-hydroxy-6',6'-(trimethylenedithio)-1'-undecenyl>benzoic acid

Base Information

Chemical Name:(+)-(1'E,10'S)-2,4-dimethoxy-6-<10'-hydroxy-6',6'-(trimethylenedithio)-1'-undecenyl>benzoic acid
CAS No.:133043-08-0
Molecular Formula:C₂₃H₃₄O₅S₂
Molecular Weight:454.652
Hs Code.:

Synonyms:(+)-(1'E,10'S)-2,4-dimethoxy-6-<10'-hydroxy-6',6'-(trimethylenedithio)-1'-undecenyl>benzoic acid

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Chemical Property of (+)-(1'E,10'S)-2,4-dimethoxy-6-<10'-hydroxy-6',6'-(trimethylenedithio)-1'-undecenyl>benzoic acid

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Technology Process of (+)-(1'E,10'S)-2,4-dimethoxy-6-<10'-hydroxy-6',6'-(trimethylenedithio)-1'-undecenyl>benzoic acid

There total 14 articles about (+)-(1'E,10'S)-2,4-dimethoxy-6-<10'-hydroxy-6',6'-(trimethylenedithio)-1'-undecenyl>benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 133043-07-9
(+)-methyl (1'E,10'S)-2,4-dimethoxy-6-<10'-hydroxy-6',6'-(trimethylenedithio)-1'-undecenyl>benzoate

: 133043-08-0
(+)-(1'E,10'S)-2,4-dimethoxy-6-<10'-hydroxy-6',6'-(trimethylenedithio)-1'-undecenyl>benzoic acid

Guidance literature:: With potassium hydroxide; In ethylene glycol; at 140 ℃;

Reference yield:

: 108-55-4
glutaric anhydride,

: 133043-08-0
(+)-(1'E,10'S)-2,4-dimethoxy-6-<10'-hydroxy-6',6'-(trimethylenedithio)-1'-undecenyl>benzoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) lithium diisopropylamide / 1.) THF, -40 deg C, 30 min 2.) THF, -78 to -60 deg C, 1 h

2: diethyl ether; methanol / 0 °C

3: 80 percent / zinc chloride, DIBAL / tetrahydrofuran / 0.5 h / -78 °C

4: 98 percent / imidazole / dimethylformamide / Ambient temperature

5: 89 percent / Raney nickel / ethanol / 1 h / Ambient temperature

6: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 30 min 2.) THF, -40 to 0 deg C, 2 h

7: 90 percent / 6percent sodium amalgam, anh. disodium hydrogen phosphate, methanol / 18 h / -20 °C

8: 78 percent / BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

9: 84 percent / 10 N aq. potassium hydroxide / ethane-1,2-diol / 2 h / 140 °C

With 1H-imidazole; methanol; potassium hydroxide; disodium hydrogenphosphate; sodium amalgam; boron trifluoride diethyl etherate; nickel; diisobutylaluminium hydride; zinc(II) chloride; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;
DOI:10.1021/jo00007a015

Reference yield:

: 133043-10-4
5-oxo-6-(p-tolylsulfinyl)hexanoic acid

: 133043-08-0
(+)-(1'E,10'S)-2,4-dimethoxy-6-<10'-hydroxy-6',6'-(trimethylenedithio)-1'-undecenyl>benzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: diethyl ether; methanol / 0 °C

2: 80 percent / zinc chloride, DIBAL / tetrahydrofuran / 0.5 h / -78 °C

3: 98 percent / imidazole / dimethylformamide / Ambient temperature

4: 89 percent / Raney nickel / ethanol / 1 h / Ambient temperature

5: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 30 min 2.) THF, -40 to 0 deg C, 2 h

6: 90 percent / 6percent sodium amalgam, anh. disodium hydrogen phosphate, methanol / 18 h / -20 °C

7: 78 percent / BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

8: 84 percent / 10 N aq. potassium hydroxide / ethane-1,2-diol / 2 h / 140 °C

With 1H-imidazole; methanol; potassium hydroxide; disodium hydrogenphosphate; sodium amalgam; boron trifluoride diethyl etherate; nickel; diisobutylaluminium hydride; zinc(II) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;
DOI:10.1021/jo00007a015