1-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanamine

Base Information

Chemical Name:1-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanamine
CAS No.:1350378-87-8
Molecular Formula:C₂₅H₂₃ClN₆O₂S₂
Molecular Weight:539.082
Hs Code.:

Synonyms:1-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanamine

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Chemical Property of 1-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanamine

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Technology Process of 1-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanamine

There total 8 articles about 1-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350378-55-0
1-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)-N-(4-methoxybenzyl)cyclobutanamine

: 1350378-87-8
1-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanamine

Guidance literature:: With water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 1.33333h;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1350378-87-8
1-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanamine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

2: lithium diisopropyl amide; iodine / tetrahydrofuran / 1.08 h / -78 °C

3: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 63 °C / Inert atmosphere

4: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed vial

5: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane / 1.33 h / 20 °C

With water; iodine; sodium hydride; sodium hydrogencarbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1350378-53-8
N-(4-methoxybenzyl)-1-(thiazol-2-yl)cyclobutanamine

: 1350378-87-8
1-(5-(5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)thiazol-2-yl)cyclobutanamine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium diisopropyl amide / tetrahydrofuran / 1.42 h / -78 - 20 °C

2: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere; Sealed vial

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane / 1.33 h / 20 °C

With water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;