2-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-thiazolcarboxylic acid

Base Information

Chemical Name:2-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-thiazolcarboxylic acid
CAS No.:1444198-78-0
Molecular Formula:C₂₁H₂₃ClN₄O₆S
Molecular Weight:494.956
Hs Code.:

Synonyms:2-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-thiazolcarboxylic acid

Suppliers and Price of 2-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-thiazolcarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-thiazolcarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-thiazolcarboxylic acid

There total 21 articles about 2-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-thiazolcarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₆Cl₄N₄O₉S

: 1444198-78-0
2-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-thiazolcarboxylic acid

Guidance literature:: C₃₃H₃₆Cl₄N₄O₉S; With hydrogenchloride; methoxybenzene; In acetic acid; at 20 ℃; for 40h;

With acetic acid; zinc; at 20 ℃; for 25h;
DOI:10.1016/j.bmc.2013.04.079

Reference yield:

: 1312769-94-0
ethyl 2-[(1R)-1-(tert-butoxycarbonylamino)propyl]thiazole 4-carboxylate

: 1444198-78-0
2-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-thiazolcarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / ethanol / 2 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 20 °C

3.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

4.1: triethylamine; dmap / N,N-dimethyl-formamide / 72 h / 0 °C

5.1: hydrogenchloride; methoxybenzene / acetic acid / 40 h / 20 °C

5.2: 25 h / 20 °C

With hydrogenchloride; dmap; water; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.079

Reference yield:

: 1444200-99-0
C₁₂H₁₈N₂O₄S

: 1444198-78-0
2-[(1R)-1-({[(6R)-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)propyl]-4-thiazolcarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 3 h / 20 °C

2.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

3.1: triethylamine; dmap / N,N-dimethyl-formamide / 72 h / 0 °C

4.1: hydrogenchloride; methoxybenzene / acetic acid / 40 h / 20 °C

4.2: 25 h / 20 °C

With hydrogenchloride; dmap; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.079